EID1 Antibody

Datasheet

Code	CSB-PA448901
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA448901(EID1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA448901(EID1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA448901(EID1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

Q9Y6B2

Target Names

EID1

Alternative Names

21 kDa pRb associated protein antibody; 21 kDa pRb-associated protein antibody; C15orf3 antibody; CBP antibody; Chromosome 15 open reading frame 3 antibody; CREBBP/EP300 inhibitor 1 antibody; CREBBP/EP300 inhibitory protein 1 antibody; CRI 1 antibody; CRI1 antibody; E1A like inhibitor of differentiation antibody; E1A-like inhibitor of differentiation 1 antibody; EID 1 antibody; EID-1 antibody; EID1 antibody; EID1_HUMAN antibody; EP300 interacting inhibitor of differentiation 1 antibody; EP300-interacting inhibitor of differentiation 1 antibody; IRO45620 antibody; MGC138883 antibody; MGC138884 antibody; NB4 apoptosis related protein antibody; PNAS 22 antibody; PNAS22 antibody; PTD014 antibody; Rb and p300 binding protein EID 1 antibody; Rb and p300 binding protein EID1 antibody; RBP21 antibody; Retinoblastoma protein associated protein antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human EID1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Gene References into Functions

EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage. PMID: 26643909
Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation. PMID: 24167073
An unexpected EID1-binding site on SHP is located at the N terminus of the receptor, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain. PMID: 24379397
This study demonstrated that overexpression of EID1 reduced hippocampal long-term potentiation and impaired spatial learning and memory function in the transgenic mice PMID: 22186421
miR-138 inhibited adipogenesis through targeting the nuclear receptor coregulator EID-1 PMID: 20486779
The role of EID1 in fibroblast biology and fibrosis is reported. PMID: 17559085
Repression of E6 and E7 oncogenes results in restoration of pRb suppressor pathways and induced apoptosis in HPV16-positive oropharyngeal squamous cell cancer cell lines. PMID: 19276448

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Subcellular Location

Nucleus. Cytoplasm.

Tissue Specificity

Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and vari

Database Links

HGNC: 1191

OMIM: 605894

KEGG: hsa:23741

STRING: 9606.ENSP00000431162

UniGene: Hs.255973

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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