EIF2S2 (Ab-67) Antibody

Datasheet

Code	CSB-PA566738
Size	US$297
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Image	Western blot analysis of extracts from K562 cells, using eIF2B (Ab-67) antibody. Western blot analysis of extracts from JK cells (Lane 2), using eIF2B (Ab-67) antiobdy. The lane on the left is treated with systhesized peptide.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EIF2S2 Polyclonal antibody

Uniprot No.

P20042

Target Names

EIF2S2

Alternative Names

DKFZp686L18198 antibody; eIF 2 beta antibody; eIF-2-beta antibody; EIF2 antibody; EIF2B antibody; EIF2beta antibody; EIF2S2 antibody; Eukaryotic initiation factor 2 beta antibody; eukaryotic initiation factor 2-beta antibody; Eukaryotic translation initiation factor 2 beta antibody; Eukaryotic translation initiation factor 2 subunit 2 antibody; Eukaryotic translation initiation factor 2 subunit 2 beta 38kDa antibody; Eukaryotic translation initiation factor 2 subunit 2 beta antibody; Eukaryotic translation initiation factor 2 subunit beta antibody; eukaryotic translation initiation factor 2; subunit 2 beta; 38kDa antibody; IF2B_HUMAN antibody; MGC8508 antibody; PPP1R67 antibody; protein phosphatase 1; regulatory subunit 67 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from N-terminal of Human eIF2B.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Gene References into Functions

Data suggest that eukaryotic translation initiation factor 2 subunit beta (eIF2beta) is a therapeutic target for lung cancer. PMID: 29624814
This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta PMID: 22813744
These findings suggest that alpha and beta subunits of eIF2 interact with each other and the beta-subunit plays a critical role both in the regulation and function of eIF2. PMID: 18639529

Protein Families

EIF-2-beta/eIF-5 family

Database Links

HGNC: 3266

OMIM: 603908

KEGG: hsa:8894

STRING: 9606.ENSP00000364119

UniGene: Hs.429180

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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