EIF4E3 Antibody

Code CSB-PA009234
Size US$100
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  • Western Blot analysis of 3T3 cells using eIF4E3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
EIF4E3
Alternative Names
EIF4E3Eukaryotic translation initiation factor 4E type 3 antibody; eIF-4E type 3 antibody; eIF-4E3 antibody; eIF4E type 3 antibody; eIF4E-3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human eIF4E3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.
Gene References into Functions
  1. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts. PMID: 28942592
  2. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules. PMID: 27578149
  3. MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma. PMID: 25403230
  4. eIF4E3 impedes oncogenic transformation and its expression is lost in some cancers. PMID: 23587918
Protein Families
Eukaryotic initiation factor 4E family
Database Links

HGNC: 31837

OMIM: 609896

KEGG: hsa:317649

STRING: 9606.ENSP00000393324

UniGene: Hs.581355

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