ELK1 Antibody, FITC conjugated

Code CSB-PA007603LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ELK1 Polyclonal antibody
Uniprot No. P19419
Target Names ELK1
Alternative Names ELK 1 antibody; Elk1 antibody; ELK1 member of ETS oncogene family antibody; ELK1 protein antibody; ELK1; ETS transcription factor antibody; ELK1_HUMAN antibody; ELK2 member of ETS oncogene family antibody; ETS domain containing protein Elk 1 antibody; ETS domain containing protein Elk1 antibody; ETS domain protein Elk1 antibody; ETS domain-containing protein Elk-1 antibody; ETS like gene 1 antibody; Member of ETS oncogene family antibody; Oncogene Elk1 antibody; Tyrosine kinase (ELK1) oncogene antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human ETS domain-containing protein Elk-1 protein (247-403AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Gene References into Functions
  1. enhanced ETS factor activity and the transcription of ETS family target genes related to spliceosome function and cell death induction via alternate MCL1 splicing, is reported. PMID: 29118074
  2. Authors found that miR-185-5p decreases HBV S1p activity by targeting ELK1. PMID: 30308183
  3. High ELK1 expression is associated with thyroid cancer progression. PMID: 30015900
  4. ID1, CTCF and ELK1 may be associated with prostate cancer, and may be potential therapeutic targets for the treatment of this disease. PMID: 29956775
  5. Study demonstrates that miR-135a regulates cell proliferation in breast cancer by targeting ELK1 and ELK3 oncogenes, and suggests that miR-135a potentially can act as a tumor suppressor. PMID: 29892795
  6. Phospho-ELK1 overexpression serves as a predictor of poor prognosis in patients with urothelial carcinoma of the upper urinary tract. PMID: 29518027
  7. TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID: 28206956
  8. This study indicated that lncrna-TCONS_00026907 was upregulated in cervical cancer and TCONS_00026907 promoted the progression of cervical cancer through inhibition of miR-143-5p and promotion of ELK1. PMID: 28544557
  9. FOXE1 interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk. PMID: 27852061
  10. Data suggest that inability of lithium, an anti-manic agent, to regulate circadian rhythms in cells from patient with bipolar disorder reflects reduced ERK1/2 activity and MAP kinase signaling through ELK1. (ERK = extracellular signal-related kinase; ELK1 = ETS-domain protein ELK1) PMID: 27216486
  11. we have shown that miR-1275 is a novel negative regulator of human visceral preadipocyte differentiation, which appears to act via post-transcriptional silencing of ELK1. PMID: 27154547
  12. Purified ELK1 and AR bound with a dissociation constant of 1.9 x 10(-8) m A purified mutant ELK1 in which the D-box and DEF motifs were disrupted did not bind AR. PMID: 27793987
  13. Study identified ELK1 as a novel target for miR- 150 which is up-regulated in apoptotic human umbilical cord vein endothelial cells. PMID: 28110404
  14. Study identified a core region encompassing nt - 118 to + 108 of IPO4 gene that is necessary for its promoter activity. Transcription factors binding to this region were screened, resulting in the identification of two members of the Ets family, Ets-like transcription factor-1 and GA binding protein, which repress or activate its promoter activity, respectively. PMID: 28254634
  15. High expression of ELK1 is associated with cholangiocarcinoma. PMID: 27658773
  16. Overexpression of PAD4 constrains the activity of EMT via suppressing Elk1 expression. PMID: 27176594
  17. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID: 26861876
  18. Downregulated expression of transcriptional activator ELK-1 may play an important role in the pathogenesis of atrial fibrillation. PMID: 26617947
  19. ELK1 is likely to be activated in prostate cancer cells and promote tumor progression. Furthermore, silodosin that inactivates ELK1 in prostate cancer cells not only inhibits their growth but also enhances the cytotoxic activity of gemcitabine. PMID: 26864615
  20. results suggest that ELK1 plays an important role in bladder tumorigenesis and cancer progression. PMID: 26342199
  21. Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells by activating the transcription factor ELK1 via the JNK signaling pathway. PMID: 26667302
  22. These findings suggest that PKCalpha expression in HCC could be stimulated by the formation of MZF-1/Elk-1 complex, which directly binds to the PKCalpha promoter. PMID: 26010542
  23. interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1. PMID: 25066273
  24. Data show that afatinib reduced Elk-1 transcription factor binding to the CIP2A protein promoter and suppressed CIP2A transcription. PMID: 25537503
  25. TNF-alpha modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1. PMID: 24121020
  26. Analysis implies a role of ELK-1 in the differences between pluripotent stem cells with distinct X chromosome inactivation statuses. PMID: 23871667
  27. Elk-1 interacts with the cell cycle kinase Aurora-A, and when Aurora inhibitors are used, P-S383-Elk-1 fails to localize to the poles and remains associated with DNA. PMID: 23322625
  28. our data suggest that preferential binding of activated Elk-1 to the IL10 rs3122605-G allele upregulates IL10 expression and confers increased risk for SLE in European Americans. PMID: 24130510
  29. Two members of the ETS (E-26) family (PEA3 and ELK-1) regulate the expression of miRNA-200b. PEA3 promotes the expression of miRNA-200b, and ELK-1 is a transcriptional repressor of miRNA-200b. PMID: 24072701
  30. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens PMID: 23940030
  31. The binding of Ets1 and Elk1 together to the proximal CIP2A promoter is absolutely required for CIP2A expression in cervical, endometrial and liver carcinoma cell lines PMID: 23117818
  32. Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3beta-dependent protein degradation. PMID: 23463670
  33. Authors define the minimal promoter region of EVI1 and demonstrate that RUNX1 and ELK1, two proteins with essential functions in hematopoiesis, regulate EVI1 in AML. PMID: 22689058
  34. Ethanol increases Pol III transcription through a response element which is composed of the overlapping Elk1 and AP-1 binding sites of the TBP promoter. The binding sites may play a role in ethanol-induced deregulation of Pol III genes in liver tumors. PMID: 23454483
  35. Strikingly, promoters bound by ELK1 without ERK2 are occupied by Polycomb group proteins that repress genes involved in lineage commitment. PMID: 23727019
  36. although ELK1 and GABPA ultimately control the same biological process, they do so by regulating different cohorts of target genes associated with cytoskeletal functions and cell migration contro PMID: 23284628
  37. Elk-1 pT417 is present in epithelial cell nuclei of various normal and cancer tissues and the number of pT417-positive cells correlates with differentiation grade of colonic adenocarcinomas. PMID: 23114923
  38. The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells. PMID: 23426362
  39. Elk1 is positively associated with estrogen receptor and Cyclin D1 expression in breast cancer. Luminal A/B Her-2 negative subtypes showed more Elk-1 activity compared to Her-2 and Basal subtype. No clinicopathologic or prognostic associations were found. PMID: 23127278
  40. This is demonstrated for the unique binding mode where a novel role for ELK1 in controlling cell migration is revealed. PMID: 22589737
  41. demonstrate that ELK-1 expression arises by a combination of leaky scanning and reinitiation, with the latter mediated by the small upstream ORF2 conserved in both spliced isoforms PMID: 22354998
  42. Although the findings showed elevated expression of Elk-1 and PKCalpha in 5637 cells, the regulator of PKCalpha in bladder cancer cells is yet to be determined. PMID: 22559731
  43. association between the expression of PKCalpha and the expression of the transcription factors Elk-1 and MZF-1 in breast cancer cell lines PMID: 22242952
  44. Activation of the Elk-1 led to an increased survival and a proliferative response with the EGF stimulation, and knocking-down the Elk-1 caused a decrease in survival of U138 glioblastoma cells. PMID: 22085529
  45. Formation of ternary complex of human biliverdin reductase-protein kinase Cdelta-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-kappaB, and inducible nitric-oxidase synthase (iNOS). PMID: 22065579
  46. DJ-1 regulates SOD1 expression through Erk1/2-Elk1 pathway in its protective response to oxidative insult. PMID: 21796667
  47. the ERK/ELK-1 cascade is involved in p53-independent induction of p21 and BAX gene expression. PMID: 21642427
  48. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PMID: 21655091
  49. AC3-33 is a novel member of the secretory family and inhibits Elk1 transcriptional activity via ERK1/2 MAP PMID: 20680465
  50. preferential activation of PTPRZ1 by HIF-2 results at least in part from cooperative binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region PMID: 20224786
  51. Data show that T417(+) Elk-1 uniquely associates with several types of inclusions present in Lewy body Disease, Alzheimer's disease, and Huntington's Disease. PMID: 20126313
  52. findings suggest that MLL-AF4 family fusion oncoproteins can activate Elk-1 through Ras/MEK/extracellular signal-regulated kinase (ERK) pathway and strongly support the role of Ras signaling in the pathogenesis of MLL-rearranged leukemia PMID: 20362031
  53. Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity. PMID: 20337593
  54. The authors now show that the inactivation of either the Elk-1 or serum response factor (SRF) binding site within the enhancer also reduces major immediate-early promoter activation and viral replication of human cytomegalovirus in fibroblasts. PMID: 20147408
  55. polymorphism rs968567 influences FADS2 gene promoter activity and alters DNA binding affinity of the transcription factor ELK1. PMID: 19546342
  56. Data show that a significant overlaps between the ELK1- and SRF-binding regions, and between ELK1- and GABPA-binding regions. PMID: 19687146
  57. Complexities in Elk-1 transcription factor function and regulation PMID: 12023815
  58. The Elk-1 R motif and the p300 CRD1 motif represent a new class of repression domains that are regulated in a context-dependent manner. PMID: 12077333
  59. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1 PMID: 12242287
  60. Bombesin-dependent activation of the transcription factor Elk-1 and significant increase of cell proliferation in prostate cancer cell lines PMID: 12409226
  61. role in signal cascade in immediate-early gene induction by anisomycin and arsenite PMID: 12660819
  62. ERK pathway activation leads to both phosphorylation of Elk-1 and loss of SUMO conjugation. This reciprocal regulation of activation and repression are coupled by MAP kinase modification of Elk-1. PMID: 12887893
  63. SUMO conjugation is a novel regulator of Elk-1 function through the control of its nuclear-cytoplasmic shuttling. PMID: 15210726
  64. transcriptional activities of ElK-1 and AP-1 are inhibited by TRIM45, a novel human RBCC/TRIM protein PMID: 15351693
  65. H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin PMID: 15576363
  66. Basal and inducible phosphorylation of Elk-1 is impaired in a patient with premature aging syndrome and insulin resistance. PMID: 15772901
  67. Data suggest that residues distal to the binding interface of DNA and Elk-1/SAP-1 may indirectly modulate the binding affinity by stabilizing the protein scaffold required for efficient DNA interaction. PMID: 15808854
  68. PKCalpha expression may be modulated by Elk-1 and MZF-1 at the transcriptional level. PMID: 16297876
  69. PI3K through p21-activated kinase 1 regulates FRA-1 proto-oncogene induction by cigarette smoke and the subsequent activation of the Elk1 and cAMP-response element-binding protein transcription factors PMID: 16490785
  70. JNK1 and JNK2 differentially regulate TBP through Elk-1, controlling c-Jun expression and cell proliferation PMID: 17074809
  71. PKC-eta-mediated glioblastoma proliferation involves MEK/mitogen-activated protein (MAP) kinase phosphorylation, activation of ERK and subsequently of Elk-1. PMID: 17146445
  72. Increased expression of transcription factor Elk-1 may play an important role in esophageal carcinogenesis. PMID: 17203534
  73. Human Rev7 (hRev7)/MAD2B/MAD2L2 is an interaction partner for Elk-1 and hRev7 acts to promote Elk-1 phosphorylation by the c-Jun N-terminal protein kinase (JNK) MAP kinases. PMID: 17296730
  74. Elk1 transcription factor targets a binding site in the TBP promoter and its occupancy of this region is reciprocal with that of Mif1. PMID: 17499043
  75. The 5' UTR controls ribosomal access to the ELK-1 AUG initiation codon. PMID: 17591614
  76. BFGF activates the MAPK and NFkappB pathways that converge on ELK1 to control production of MMP13 by articular chondrocytes. PMID: 17724016
  77. Elk-1 exerted opposite effects on hSlu7 transcription:Elk-1 protein represses transcription in a dose-dependent manner PMID: 17804646
  78. Elk-1 activated transcription of the HTLV-1 long terminal repeat (LTR), and mutations within either of the TCF sites or the CArG box reduced responsiveness of the LTR to Elk-1. PMID: 17898074
  79. Hemin activated Elk-1, SRF, and NF-kappaB and promoted their interaction with the Egr-1 promoter PMID: 17967787
  80. MDMX basal promoter activity requires c-Ets-1 and Elk-1. c-Ets-1 and Elk-1 control MDMX transcription and contribute to the suppression of p53 activity. PMID: 18172009
  81. These results strongly support that Elk-1 protein is a novel binding-protein partner for FAK, a finding that significantly broadens the potential functioning of FAK and Elk-1. PMID: 18247360
  82. Results suggest that Elk-1 is anchored to neuronal microtubules in resting or unstimulated cells, and upon stimulation is phosphorylated, which relocalizes phospho-Elk-1 to the nucleus in neurons. PMID: 19013529
  83. Elk-1 is involved in upregulating HRI expression during stress along with a co-activator p300, while MZF-1 along with HDAC-1 is instrumental in its downregulation during hemin treatment. PMID: 19133234
  84. Constitutive androstane receptor expression may be mediated by phosphorylated Elk-1 via the SAPK signaling pathway PMID: 19302787
  85. FcgammaRIIIB, but not FcgammaRIIA, activates a unique signaling pathway leading to the nuclear-restricted phosphorylation of ERK and Elk-1, independently of Syk, PI3K, or MEK PMID: 19342628

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Subcellular Location Nucleus
Protein Families ETS family
Tissue Specificity Lung and testis.
Database Links

HGNC: 3321

OMIM: 311040

KEGG: hsa:2002

STRING: 9606.ENSP00000247161

UniGene: Hs.181128

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