EMC1 Antibody

Datasheet

Code	CSB-PA208661
Size	US$166
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Image	Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA208661(EMC1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 15 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q8N766

Target Names

EMC1

Alternative Names

2700016F22Rik antibody; C230096C10Rik antibody; Emc1 antibody; ER membrane protein complex subunit 1 antibody; Hypothetical protein LOC23065 antibody; K0090_HUMAN antibody; KIAA0090 antibody; mKIAA0090 antibody; OTTHUMP00000215527 antibody; PSEC0263 antibody; RIKEN cDNA C230096C10 gene antibody; RP1-43E13.1 antibody; RP23-371E13.1 antibody; Uncharacterized protein KIAA0090 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human EMC1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).

Gene References into Functions

The authors find that a member of the endoplasmic reticulum membrane protein complex (EMC) called EMC1 promotes SV40 virus endoplasmic reticulum membrane transport and infection. PMID: 28012275
EMC1 is a gene in which either biallelic or monoallelic variants might lead to a syndrome including intellectual disability and preferential degeneration of the cerebellum. PMID: 26942288

Involvement in disease

Cerebellar atrophy, visual impairment, and psychomotor retardation (CAVIPMR)

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Families

EMC1 family

Database Links

HGNC: 28957

OMIM: 616846

KEGG: hsa:23065

STRING: 9606.ENSP00000420608

UniGene: Hs.439200

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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