ENC1 Antibody

Datasheet

Code	CSB-PA007663LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: MCF7 whole cell lysate(20µg), A549 whole cell lysate(20µg), SY5Y whole cell lysate(20µg), U251 whole cell lysate(20µg),Mouse Kidney tissue lysate(20µg) All lanes: ENC1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/20000 dilution Predicted band size: 67, 58 kDa Observed band size: 58 kDa Exposure time: 10s
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ENC1 Polyclonal antibody

Uniprot No.

O14682

Target Names

ENC1

Alternative Names

CCL 28 antibody; CCL28 antibody; Ectoderm neural cortex protein 1 antibody; Ectoderm-neural cortex protein 1 antibody; Ectodermal neural cortex (with BTB like domain) antibody; ENC 1 antibody; ENC-1 antibody; ENC1 antibody; ENC1_HUMAN antibody; FLJ39259 antibody; Kelch like 35 antibody; Kelch like 37 antibody; Kelch-like protein 37 antibody; KLHL 35 antibody; KLHL35 antibody; KLHL37 antibody; NRPB antibody; Nuclear matrix protein NRP/B antibody; Nuclear restricted protein BTB domain like (brain) antibody; OTTHUMP00000128235 antibody; OTTHUMP00000222054 antibody; p53 induced gene 10 protein antibody; p53-induced gene 10 protein antibody; PIG 10 antibody; PIG10 antibody; TP53I10 antibody; Tumor protein p53 inducible protein 10 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human ENC1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ENC1 Antibody (Product code: CSB-PA007663LA01HU) is Non-conjugated. For ENC1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007663LB01HU	ENC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007663LC01HU	ENC1 Antibody, FITC conjugated
Biotin	CSB-PA007663LD01HU	ENC1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.

Gene References into Functions

ENC1 interacts with the phosphorylated p62 to impair autophagic degradation of mutant huntingtin protein aggregates. PMID: 26637326
we identified ENC1 and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evidence supporting a potential role in the dissociation of cognition and neuropathology in an aging population. PMID: 28441426
results suggest that upregulation of ENC-1 contributes to the development of HCL and provides new information on the possible dysregulation of ENC-1 including expression of a novel antisense gene, ENC-1AS PMID: 15459180
NRP/B enhances oxidative stress responses in breast cancer cells via the Nrf2 pathway, identifying a novel role of nuclear matrix protein(s) in oxidative stress responses. PMID: 17875699
NRP/B mutations impair Nrf2-dependent NQO1 induction in primary brain tumors. PMID: 18981988
ENC1 functions as a negative regulator of Nrf2 through suppressing Nrf2 protein translation. PMID: 19424503

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Subcellular Location

Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton.

Tissue Specificity

Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma

Database Links

HGNC: 3345

OMIM: 605173

KEGG: hsa:8507

STRING: 9606.ENSP00000306356

UniGene: Hs.104925

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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