EPHA10 Antibody

Code CSB-PA008922
Size US$100
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Product Details

Uniprot No.
Target Names
EPHA10
Alternative Names
EPH receptor A10 antibody; EPHA 10 antibody; Epha10 antibody; EphA10s protein antibody; EPHAA_HUMAN antibody; Ephrin type A receptor 10 antibody; Ephrin type-A receptor 10 antibody; FLJ16103 antibody; FLJ33655 antibody; MGC43817 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human EphA10.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Gene References into Functions
  1. we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage. PMID: 28427223
  2. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
  3. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers PMID: 24946238
  4. Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here. PMID: 24924629
  5. EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression. PMID: 24403271
  6. EPHA10 does not interact with EPHB6 in breast neoplasms PMID: 21737611
  7. CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10. PMID: 18819711

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity
Mainly expressed in testis.
Database Links

HGNC: 19987

OMIM: 611123

KEGG: hsa:284656

STRING: 9606.ENSP00000362139

UniGene: Hs.129435

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