EPHA10 Antibody

Code CSB-PA915371
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA915371(EPHA10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No. Q5JZY3
Target Names EPHA10
Alternative Names EPH receptor A10 antibody; EPHA 10 antibody; Epha10 antibody; EphA10s protein antibody; EPHAA_HUMAN antibody; Ephrin type A receptor 10 antibody; Ephrin type-A receptor 10 antibody; FLJ16103 antibody; FLJ33655 antibody; MGC43817 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Fusion protein of Human EPHA10
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Gene References into Functions
  1. we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage. PMID: 28427223
  2. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
  3. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers PMID: 24946238
  4. Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here. PMID: 24924629
  5. EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression. PMID: 24403271
  6. EPHA10 does not interact with EPHB6 in breast neoplasms PMID: 21737611
  7. CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10. PMID: 18819711

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Subcellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity Mainly expressed in testis.
Database Links

HGNC: 19987

OMIM: 611123

KEGG: hsa:284656

STRING: 9606.ENSP00000362139

UniGene: Hs.129435

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