EPHA7 Antibody

1. receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways. PMID: 29022918
2. these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7. PMID: 28604772
3. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
4. Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway. PMID: 26936314
5. Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells. PMID: 25968442
6. Authors observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not. PMID: 25855521
7. miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs. PMID: 24927112
8. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. PMID: 21964981
9. The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma. PMID: 21609571
10. Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue. PMID: 22246354
11. EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas. PMID: 22036564
12. EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma. PMID: 20302756
13. analysis of the secreted form of EphA7 in lung cancer PMID: 20126984
14. downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis PMID: 16007213
15. EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033) PMID: 17669470
16. siRNA-mediated suppression of ALL1/AF4 in SEMK2 cells carrying the t(4;11) chromosome translocation resulted in down-regulation of EphA7 PMID: 17726105
17. EphA7 protein may have a role in progression of glioblastoma multiforme PMID: 18366728
18. epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis PMID: 18821581

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HGNC: 3390

OMIM: 602190

KEGG: hsa:2045

STRING: 9606.ENSP00000358309

UniGene: Hs.73962