ESRRB Antibody

Code CSB-PA007836LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate
    All lanes: ESRRB antibody at 3.7µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 49, 57, 56 kDa
    Observed band size: 49 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ESRRB Polyclonal antibody
Uniprot No.
Target Names
ESRRB
Alternative Names
Err 2 antibody; ERR b antibody; ERR B2 antibody; ERR beta 2 antibody; ERR beta antibody; ERR beta-2 antibody; ERR-beta antibody; Err2 antibody; ERR2_HUMAN antibody; ERRB 2 antibody; ERRb antibody; ERRB2 antibody; ERRbeta 2 antibody; ERRbeta antibody; ESR L2 antibody; ESRL 2 antibody; ESRL2 antibody; Esrrb antibody; Estrogen receptor like 2 antibody; Estrogen receptor related 2 antibody; Estrogen receptor-like 2 antibody; Estrogen-related receptor beta antibody; Estrrb antibody; Nr3b2 antibody; Nuclear receptor ERRB2 antibody; Nuclear receptor subfamily 3 group B member 2 antibody; Orphan nuclear receptor antibody; Steroid hormone receptor ERR 2 antibody; Steroid hormone receptor ERR2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ESRRB Antibody (Product code: CSB-PA007836LA01HU) is Non-conjugated. For ESRRB Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007836LB01HU ESRRB Antibody, HRP conjugated ELISA
FITC CSB-PA007836LC01HU ESRRB Antibody, FITC conjugated
Biotin CSB-PA007836LD01HU ESRRB Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation.; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.
Gene References into Functions
  1. the calcium level was associated with genetic variations in AMELX, AMNB and ESRRB. AMELX and AMNB are involved in enamel mineralization. Mutations in both these genes are responsible for the amelogenesis imperfecta phenotype (OMIN), which supports their link with enamel alterations as well as enamel mineralization. PMID: 28395292
  2. SNP (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta is associated with audiometric temporary threshold shift. PMID: 27399974
  3. ESRRbeta is mislocalized in human myocardium samples with idiopathic dilated cardiomyopathy, suggesting a possible role for ESRRbeta in the pathogenesis of idiopathic dilated cardiomyopathy in humans PMID: 28130335
  4. The rs1676303 TT (P=0.02) and rs6574293 GG (P=0.04) genotypes of ESRRB were associated with RCD and TMD, respectively. PMID: 26584852
  5. analysis of Esrrb target genes indicates Esrrb may be an important factor in regulating cell proliferation PMID: 26627478
  6. ERRbeta has a role in estrogen-dependent cellular function including cancer cell proliferation PMID: 25805499
  7. The significant association and the presence of high-risk haplotypes identified in the ESRRB gene confirm the association of variants in ESRRB and rotator cuff disease. PMID: 25219474
  8. study concludes ESRRB, a gene when mutated causes a form of hearing impairment, also contributes to dental decay likely by influencing the formation of an enamel surface more susceptible to demineralization under acidic conditions PMID: 25023176
  9. ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin PMID: 24667650
  10. This is the first report of DFNB35 mutations in the Czech Republic and it seems to be a rare cause of non-syndromic hearing loss. PMID: 22951369
  11. A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family. PMID: 21802533
  12. Data confirm the up-regulation of ER-beta as the principal receptor involved in the progression of human endometriosis. PMID: 21561608
  13. ERRbeta plays a repressor role in the Nrf2-ARE pathway PMID: 17920186
  14. ERRbeta performs a tumor suppressing function in prostate cancer cells. PMID: 18071305
  15. Data indicate that ESRRB is essential for inner-ear development and function and a frame shift mutation in ESRRB results in non-syndromic hearing impairment. PMID: 18179891
  16. Sequence analysis of the ESRRB gene in the affected individuals of the original DFNB35 family and in three other DFNB35-linked consanguineous families from Pakistan revealed four missense mutations. PMID: 18179891
  17. ERRbeta protein was localized to cell nuclei within multiple endometrial cell types including the glands, stroma, endothelium and immune cells, including uterine natural killer (uNK) cells and macrophages throughout normal menstrual cycle. PMID: 18775884
  18. Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells PMID: 18957414
  19. Short-form hERRbeta lacks an F domain and is the matched homolog of mouse and rat ERRbeta proteins in human. However, hERRbeta2-Delta10 and the previously reported hERRbeta2 isoforms are primate specific. PMID: 16332939

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Involvement in disease
Deafness, autosomal recessive, 35 (DFNB35)
Subcellular Location
Nucleus. Cytoplasm. Chromosome.
Protein Families
Nuclear hormone receptor family, NR3 subfamily
Database Links

HGNC: 3473

OMIM: 602167

KEGG: hsa:2103

STRING: 9606.ENSP00000370270

UniGene: Hs.435845

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