Efna1 Antibody

Rare Species
Code CSB-PA007460LA01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Efna1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Efna1 antibody; Epgl1 antibody; Lerk1 antibody; Ephrin-A1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; LERK-1 antibody; Immediate early response protein B61) [Cleaved into: Ephrin-A1 antibody; secreted form] antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Ephrin-A1 protein (18-182AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated

The Efna1 Antibody (Product code: CSB-PA007460LA01RA) is Non-conjugated. For Efna1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007460LB01RA Efna1 Antibody, HRP conjugated ELISA
FITC CSB-PA007460LC01RA Efna1 Antibody, FITC conjugated
Biotin CSB-PA007460LD01RA Efna1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.; [Ephrin-A1, secreted form]: Secreted.
Protein Families
Ephrin family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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