Efna1 Antibody

Code CSB-PA007460LA01RA
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Efna1 Polyclonal antibody
Uniprot No. P97553
Target Names Efna1
Alternative Names Efna1 antibody; Epgl1 antibody; Lerk1 antibody; Ephrin-A1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; LERK-1 antibody; Immediate early response protein B61) [Cleaved into: Ephrin-A1 antibody; secreted form] antibody
Raised in Rabbit
Species Reactivity Rat
Immunogen Recombinant Rat Ephrin-A1 protein (18-182AA)
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated

The Efna1 Antibody (Product code: CSB-PA007460LA01RA) is Non-conjugated. For Efna1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007460LB01RA Efna1 Antibody, HRP conjugated ELISA
FITC CSB-PA007460LC01RA Efna1 Antibody, FITC conjugated
Biotin CSB-PA007460LD01RA Efna1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.; [Ephrin-A1, secreted form]: Secreted.
Protein Families Ephrin family
Database Links

KEGG: rno:94268

STRING: 10116.ENSRNOP00000027920

UniGene: Rn.8427

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