Ephrin-A1 is a protein in humans that is encoded by EFNA1 gene. Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK.
The following EFNA1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EFNA1 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007460LA01RA | Efna1 Antibody | Rat | ELISA |
EFNA1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007460ESR1HU | EFNA1 Antibody | Human | ELISA, IHC |
CSB-PA551061 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA002367 | EFNA1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA256498 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA999540 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
EFNA1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-EP007460RA | Recombinant Rat Ephrin-A1 (Efna1) | E.coli |
CSB-EP007460RAe0 | Recombinant Rat Ephrin-A1 (Efna1) | E.coli |
CSB-YP007460RA | Recombinant Rat Ephrin-A1 (Efna1) | Yeast |
CSB-BP007460RA CSB-MP007460RA CSB-EP007460RA-B |
Recombinant Rat Ephrin-A1 (Efna1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007460HU CSB-BP007460HU CSB-MP007460HU CSB-EP007460HU-B |
Recombinant Human Ephrin-A1 (EFNA1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP007460HU | Recombinant Human Ephrin-A1 (EFNA1), partial | E.coli |
CSB-AP005711HU | Recombinant Human Ephrin-A1 (EFNA1) (Active) | Mammalian cell |
EFNA1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP007460MO CSB-EP007460MO CSB-BP007460MO CSB-MP007460MO CSB-EP007460MO-B |
Recombinant Mouse Ephrin-A1 (Efna1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP005771MO | Recombinant Mouse Ephrin-A1 (Efna1), partial (Active) | Mammalian cell |
EFNA1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP007460XBE CSB-EP007460XBE CSB-BP007460XBE CSB-MP007460XBE CSB-EP007460XBE-B |
Recombinant Xenopus laevis Ephrin-A1 (efna1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP007460BO CSB-EP007460BO CSB-BP007460BO CSB-MP007460BO CSB-EP007460BO-B |
Recombinant Bovine Ephrin-A1 (EFNA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL007460HU | Human Ephrin-A1(EFNA1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
EFNA1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL007460MO | Mouse Ephrin-A1(EFNA1) ELISA kit | serum, plasma, tissue homogenates | 23.43 pg/mL |