F13B Antibody

Code CSB-PA007922LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: 293 whole cell lysate
    All lanes: F13B antibody at 4.17µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 76 kDa
    Observed band size: 76 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) F13B Polyclonal antibody
Uniprot No.
Target Names
F13B
Alternative Names
F13B antibody; Coagulation factor XIII B chain antibody; Fibrin-stabilizing factor B subunit antibody; Protein-glutamine gamma-glutamyltransferase B chain antibody; Transglutaminase B chain antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Coagulation factor XIII B chain protein (260-403AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The F13B Antibody (Product code: CSB-PA007922LA01HU) is Non-conjugated. For F13B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007922LB01HU F13B Antibody, HRP conjugated ELISA
FITC CSB-PA007922LC01HU F13B Antibody, FITC conjugated
Biotin CSB-PA007922LD01HU F13B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Gene References into Functions
  1. In VTE patients the changes of FXIII level and their effect on the risk of VTE show considerable sex-specific differences. Intron K polymorphism results in decreased FXIII levels, but does not influence the risk of VTE. PMID: 28865246
  2. The results suggest that plasma FXIII levels are subjected to multifactorial regulation with age, fibrinogen level and FXIII-B intron K polymorphism being the major determinants. Their effect on FXIII levels might influence the risk of thrombotic diseases. PMID: 27821352
  3. Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype. PMID: 26159793
  4. The FXIII-B intron K nt29756 G allele was associated with significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. PMID: 25569091
  5. Changes in plasma levels of FXIIIB are associated with cognitive decline in the elderly. PMID: 26088309
  6. Here, we update the knowledge about the pathophysiology of factor XIII deficiency and its therapeutic options. [review] PMID: 24503678
  7. Case Report: congenital FXIII-B deficiency in which alloantibodies developed to exogenous FXIII-B. PMID: 23407795
  8. FXIIIb subunit is found to be within normal range in eight Tunisian famillies with congenital factor XIII deficiency caused by two mutations, while expression of the FXIIIA subunit gene is decreased or undetectable. PMID: 19937244
  9. Develop ELISA/chemoluminescence assay demonstrating that FXIII-A and FXIII-B are low concentration components of tear proteome. PMID: 20079358
  10. role of FXIIIB in modifying catalytic activity of FXIIIA2 during factor XIII mediated crosslinking of fibrinogen PMID: 11816711
  11. F13 B subunit antigen may have a role in susceptibility to stroke based on this study of family members of patients in South Asia PMID: 15634282
  12. Genetic variants of factor XIIIb were evaluated on the effects of survival in myocardial infarction. PMID: 17515963
  13. at least 3 out of the 10 Sushi domains of FXIII-B have the distinct function of forming a homodimer and a heterotetramer, which should be ascribed to the differences in their amino acid sequences PMID: 18652485
  14. A specific colorimetric assay for measuring FXIIIB activity is reported. PMID: 19646949

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Involvement in disease
Factor XIII subunit B deficiency (FA13BD)
Subcellular Location
Secreted.
Database Links

HGNC: 3534

OMIM: 134580

KEGG: hsa:2165

STRING: 9606.ENSP00000356382

UniGene: Hs.435782

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