FAM175A Antibody

1. Our data also suggest how ataxia telangiectasia mutated (ATM)-dependent BRCA1 dimerization may stabilize self-association of the entire BRCA1-A complex. PMID: 28009280
2. Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied. PMID: 27270457
3. Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR. PMID: 26778126
4. The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition. PMID: 22357538
5. low expression correlates with better response to chemotherapy and longer survival in patients with advanced non small-cell lung cancer PMID: 21529986
6. CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage. PMID: 17643121
7. CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response. PMID: 17643122
8. Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene. PMID: 18270812
9. examined RAP80 and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer PMID: 19415121

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HGNC: 25829

OMIM: 114480

KEGG: hsa:84142

STRING: 9606.ENSP00000369857

UniGene: Hs.334772