FAM83D Antibody, HRP conjugated

Code CSB-PA887979LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM83D Polyclonal antibody
Uniprot No.
Target Names
FAM83D
Alternative Names
2310007D09Rik antibody; BB104611 antibody; C20orf129 antibody; CHICA antibody; dJ616B8.3 antibody; FA83D antibody; FA83D_HUMAN antibody; FAM83D antibody; Family with sequence similarity 83; member D antibody; FLJ38341 antibody; MGC92947 antibody; Protein FAM83D antibody; RGD1565583 antibody; RP23-119H5.1 antibody; Spindle protein CHICA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein FAM83D protein (339-470AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Gene References into Functions
  1. FAM83D promotes HCC recurrence by promoting CD44 expression and CD44+ CSCs malignancy. PMID: 27769048
  2. Higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer. PMID: 26678035
  3. upregulation of FAM83D, a potential oncotarget gene, may be triggered by epigenetic events and can contribute to hepatocarcinogenesis PMID: 26125229
  4. NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs. PMID: 26652654
  5. Taken together, these results demonstrate that FAM83D is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC. PMID: 25646692
  6. Results demonstrate that FAM83D has prognostic value for breast cancer patients and is a novel oncogene in breast cancer development that at least in part acts through mTOR hyper-activation by inhibiting FBXW7. PMID: 24344117
  7. interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression PMID: 18485706

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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
FAM83 family
Tissue Specificity
Expressed in the testis.
Database Links

HGNC: 16122

KEGG: hsa:81610

STRING: 9606.ENSP00000217429

UniGene: Hs.726442

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