FAM83D Antibody

Code CSB-PA887979LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: K562 whole cell lysate, 293T whole cell lysate
    All lanes: FAM83D antibody at 4.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 65, 63 kDa
    Observed band size: 65 kDa

  • Immunofluorescence staining of HepG2 cells with CSB-PA887979LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM83D Polyclonal antibody
Uniprot No.
Target Names
FAM83D
Alternative Names
2310007D09Rik antibody; BB104611 antibody; C20orf129 antibody; CHICA antibody; dJ616B8.3 antibody; FA83D antibody; FA83D_HUMAN antibody; FAM83D antibody; Family with sequence similarity 83; member D antibody; FLJ38341 antibody; MGC92947 antibody; Protein FAM83D antibody; RGD1565583 antibody; RP23-119H5.1 antibody; Spindle protein CHICA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein FAM83D protein (339-470AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FAM83D Antibody (Product code: CSB-PA887979LA01HU) is Non-conjugated. For FAM83D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA887979LB01HU FAM83D Antibody, HRP conjugated ELISA
FITC CSB-PA887979LC01HU FAM83D Antibody, FITC conjugated
Biotin CSB-PA887979LD01HU FAM83D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

FAM83D antibody is generated from rabbits immunized with a recombinant peptide between 339-470 amino acids from the human FAM83D. Its purity is greater than 95% using protein G purified. This FAM83D antibody can be used to detect the human FAM83D protein in ELISA, WB, and IF applications.

The FAM83D protein mainly regulates cell proliferation and differentiation. It has been shown to promote epithelial-mesenchymal transition (EMT) by activating the expression of genes that are involved in cell migration and invasion. FAM83D dysregulation has been associated with various pathological conditions, including cancer, inflammatory disorders, and developmental defects.

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Target Background

Function
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Gene References into Functions
  1. FAM83D promotes HCC recurrence by promoting CD44 expression and CD44+ CSCs malignancy. PMID: 27769048
  2. Higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer. PMID: 26678035
  3. upregulation of FAM83D, a potential oncotarget gene, may be triggered by epigenetic events and can contribute to hepatocarcinogenesis PMID: 26125229
  4. NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs. PMID: 26652654
  5. Taken together, these results demonstrate that FAM83D is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC. PMID: 25646692
  6. Results demonstrate that FAM83D has prognostic value for breast cancer patients and is a novel oncogene in breast cancer development that at least in part acts through mTOR hyper-activation by inhibiting FBXW7. PMID: 24344117
  7. interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression PMID: 18485706

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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
FAM83 family
Tissue Specificity
Expressed in the testis.
Database Links

HGNC: 16122

KEGG: hsa:81610

STRING: 9606.ENSP00000217429

UniGene: Hs.726442

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