FBXL20 Antibody

Code CSB-PA822228LA01HU
Size US$166
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Image
  • IHC image of CSB-PA822228LA01HU diluted at 1:800 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXL20 Polyclonal antibody
Uniprot No.
Target Names
FBXL20
Alternative Names
FBXL20 antibody; FBL2F-box/LRR-repeat protein 20 antibody; F-box and leucine-rich repeat protein 20 antibody; F-box/LRR-repeat protein 2-like antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/LRR-repeat protein 20 protein (1-137AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FBXL20 Antibody (Product code: CSB-PA822228LA01HU) is Non-conjugated. For FBXL20 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA822228LB01HU FBXL20 Antibody, HRP conjugated ELISA
FITC CSB-PA822228LC01HU FBXL20 Antibody, FITC conjugated
Biotin CSB-PA822228LD01HU FBXL20 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission.
Gene References into Functions
  1. which provides a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 and the associated Skp1-Cullin1 complex, leading to inhibition of autophagy and receptor endocytosis PMID: 25593308
  2. study concludes FBXL20 plays an essential role in the carcinogenesis of colorectal adenocarcinoma and promotes carcinogenesis through the regulation of the Wnt signaling pathway and caspase activation PMID: 23023584
Subcellular Location
Cytoplasm.
Database Links

HGNC: 24679

OMIM: 609086

KEGG: hsa:84961

STRING: 9606.ENSP00000264658

UniGene: Hs.462946

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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