FEM1B Antibody

Datasheet
Code CSB-PA942031
Size US$299
Uniprot No. Q9UK73
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA942031(FEM1B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA942031(FEM1B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human FEM1B
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:25-1:100
Relevance This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias fem-1 homolog b (C. elegans)
Immunogen Species Homo sapiens (Human)
Target Names FEM1B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Subcellular Location Cytoplasm, Nucleus
Protein Families Fem-1 family
Tissue Specificity Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Database Links

HGNC: 3649

OMIM: 613539

KEGG: hsa:10116

STRING: 9606.ENSP00000307298

UniGene: Hs.362733

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