FEM1B Antibody

Datasheet
Code CSB-PA891718LA01HU
Size US$299
Uniprot No. Q9UK73
Image
  • Western Blot
    Positive WB detected in: U87 whole cell lysate, Mouse heart tissue
    All lanes: FEM1B antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 71 kDa
    Observed band size: 71 kDa
Immunogen Recombinant Human Protein fem-1 homolog B protein (400-627AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, WB; Recommended dilution: WB:1:1000-1:5000
Relevance Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha), FEM1B, F1AA KIAA0396
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Research Area Cell Biology
Target Names FEM1B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Subcellular Location Cytoplasm, Nucleus
Protein Families Fem-1 family
Tissue Specificity Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Database Links

HGNC: 3649

OMIM: 613539

KEGG: hsa:10116

STRING: 9606.ENSP00000307298

UniGene: Hs.362733

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