FETUB Antibody

Code CSB-PA218023
Size US$166
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  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, A172 cells, Primary antibody: CSB-PA218023(FETUB Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details

Uniprot No.
Target Names
FETUB
Alternative Names
16G2 antibody; 2310011O17Rik antibody; AI255764 antibody; D17980 antibody; Fet antibody; Fetub antibody; FETUB_HUMAN antibody; Fetuin beta antibody; Fetuin-B antibody; Fetuin-like protein antibody; Fetuin-like protein IRL685 antibody; Gugu antibody; IRL685 antibody; Pp63 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human FETUB
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.
Gene References into Functions
  1. High Serum fetuin-B expression is associated with insulin resistance. PMID: 29194974
  2. fetuin B may serve as a potential biomarker for coronary artery disease PMID: 28822077
  3. Increased serum fetuin-B level was significantly associated with higher risk of insulin resistance. Common genetic variants of FETUB SNPs (rs4686434, rs6785067, and rs3733159) were significantly associated with serum fetuin-B concentrations but were not associated with insulin resistance. PMID: 29390354
  4. serum level of fetuin B in the control subjects was lower than it in nonalcoholic fatty liver disease patients. fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD. PMID: 27628583
  5. Further studies need to elucidate factors contributing to fetuin B regulation in humans, as well as the pathophysiological significance of fetuin B upregulation in gestational diabetes PMID: 28183456
  6. Data indicate that fetuin-B was one of the highly expressed serum proteins in acute myocardial infarction. PMID: 25671698
  7. Reduced expression of fetuin-b led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels. PMID: 22739111
  8. serum fetuin has a role in processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells PMID: 15280384
  9. results support the hypothesis that fetuin-A serum levels are associated with bone cell activity PMID: 16797392

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Subcellular Location
Secreted.
Protein Families
Fetuin family
Tissue Specificity
Liver and testis.
Database Links

HGNC: 3658

OMIM: 605954

KEGG: hsa:26998

STRING: 9606.ENSP00000265029

UniGene: Hs.81073

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