FGF11 Antibody

Code CSB-PA006109
Size US$119
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  • Western Blot analysis of NIH-3T3 Hela cells using FGF-11 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
FGF11
Alternative Names
FGF 11 antibody; FGF-11 antibody; FGF11 antibody; FGF11_HUMAN antibody; FHF 3 antibody; FHF-3 antibody; FHF3 antibody; Fibroblast growth factor 11 antibody; Fibroblast growth factor homologous factor 3 antibody; FLJ16061 antibody; MGC102953 antibody; MGC45269 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human FGF-11.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Probably involved in nervous system development and function.
Gene References into Functions
  1. Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs). PMID: 29852165
  2. FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents PMID: 28097375
  3. Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). PMID: 27538493
  4. these results suggest a cross-regulation between HIF-1alpha and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1alpha. PMID: 28027390
  5. Study found that FGF11 expression can be induced through HIF-1 binding sites in its promoter region suggesting that FGF11 acts as a novel modulator of hypoxia-induced pathological processes such as tumor progression. PMID: 26323829
  6. these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-->miRNA-541-->AR-->MMP9 signaling. PMID: 25135278

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Protein Families
Heparin-binding growth factors family
Tissue Specificity
Nervous system.
Database Links

HGNC: 3667

OMIM: 601514

KEGG: hsa:2256

STRING: 9606.ENSP00000293829

UniGene: Hs.655193

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