FKBP3 Antibody

Datasheet

Code	CSB-PA008699HA01HU
Size	US$166
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Image	Western blot All lanes: FKBP3 antibody at 4µg/ml Lane 1: Hela whole cell lysate Lane 2: A431 whole cell lysate Lane 3: PC-3 whole cell lysate Lane 4: Jurkat whole cell lysate Lane 5: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA008699HA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008699HA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA008699HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FKBP3 Polyclonal antibody

Uniprot No.

Q00688

Target Names

FKBP3

Alternative Names

25 kDa FK506-binding protein antibody; 25 kDa FKBP antibody; FK506 binding protein 25 T cell antibody; FK506 binding protein 25; T cell; 25-KD antibody; FK506 binding protein 3 (25kD) antibody; FK506-binding protein 3 antibody; FKBP 25 antibody; FKBP 3 antibody; FKBP-25 antibody; FKBP-3 antibody; FKBP25 antibody; FKBP3 antibody; FKBP3_HUMAN antibody; Immunophilin FKBP25 antibody; Peptidyl-prolyl cis-trans isomerase FKBP3 antibody; PPIase antibody; PPIase FKBP3 antibody; Rapamycin binding protein antibody; Rapamycin-selective 25 kDa immunophilin antibody; Rotamase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP3 protein (2-224AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FKBP3 Antibody (Product code: CSB-PA008699HA01HU) is Non-conjugated. For FKBP3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008699HB01HU	FKBP3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008699HC01HU	FKBP3 Antibody, FITC conjugated
Biotin	CSB-PA008699HD01HU	FKBP3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.

Gene References into Functions

Taken together, these data clearly show that FKBP3/Sp1/HDAC2/p27 control cell proliferation during non-small cell lung cancer development. PMID: 28839465
Data show that the N-terminus of FK506 binding protein-25 (FKBP25) is anchored to regions of dsRNA, whereas the FKBP domain is free to interact with neighboring proteins. PMID: 29036638
Structural basis for nucleic acid recognition by FKBP25 has been uncovered. PMID: 26762975
proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing PMID: 24998444
FKBP25 is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit. PMID: 24840943
structure of a unique N-terminal domain motif in the FKBP family, FKBP25(1-73), high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted in a novel arrangement; called Basic Tilted Helix Bundle (BTHB) domain. PMID: 24667607
FKBP3, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53. PMID: 19166840

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Subcellular Location

Nucleus.

Protein Families

FKBP-type PPIase family

Database Links

HGNC: 3719

OMIM: 186947

KEGG: hsa:2287

STRING: 9606.ENSP00000216330

UniGene: Hs.509226

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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