FKBP6 Antibody

Datasheet

Code	CSB-PA008702LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA008702LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008702LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA008702LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: HEK293 whole cell lysate All lanes: FKBP6 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38, 37, 34 kDa Observed band size: 38 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FKBP6 Polyclonal antibody

Uniprot No.

O75344

Target Names

FKBP6

Alternative Names

36 kDa FK506 binding protein antibody; 36 kDa FK506-binding protein antibody; 36 kDa FKBP antibody; EC 5.2.1.8 antibody; FK506 binding protein 6 antibody; FK506-binding protein 6 antibody; FKBP 36 antibody; FKBP-36 antibody; FKBP-6 antibody; FKBP36 antibody; fkbp6 antibody; FKBP6_HUMAN antibody; Immunophilin FKBP36 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP6 antibody; PPIase antibody; PPIase FKBP6 antibody; Rotamase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Inactive peptidyl-prolyl cis-trans isomerase FKBP6 protein (101-327AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FKBP6 Antibody (Product code: CSB-PA008702LA01HU) is Non-conjugated. For FKBP6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008702LB01HU	FKBP6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008702LC01HU	FKBP6 Antibody, FITC conjugated
Biotin	CSB-PA008702LD01HU	FKBP6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

Gene References into Functions

Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80). PMID: 24241165
278A polymorphism of FKBP6 gene was associated with idiopathic azoospermia, while C/T, 370G/A, 430G/C, 467T/C, 468G/A polymorphisms might be very rare in Chinese population. PMID: 15696470
may play a role in modifying the susceptibility to idiopathic spermatogenic impairment in human; allele A of c.216C>A seems to be a protective factor for the development of male infertility PMID: 17307919
clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats PMID: 18529014
FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH PMID: 19001379

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Involvement in disease

FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).

Subcellular Location

Cytoplasm, cytosol. Nucleus. Chromosome.

Protein Families

FKBP6 family

Tissue Specificity

Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.

Database Links

HGNC: 3722

OMIM: 604839

KEGG: hsa:8468

STRING: 9606.ENSP00000252037

UniGene: Hs.661266

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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