FRK Antibody

1. our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. PMID: 28077797
2. Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. PMID: 27665472
3. antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. PMID: 25783528
4. our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. PMID: 24792491
5. FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. PMID: 24969324
6. exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors PMID: 24735922
7. Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. PMID: 23318459
8. The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. PMID: 23267173
9. these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion PMID: 22790444
10. Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. PMID: 21665990
11. Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. PMID: 21074287
12. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase PMID: 12569567
13. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. PMID: 12725532
14. Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. PMID: 15082191
15. Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. PMID: 19345329

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HGNC: 3955

OMIM: 606573

KEGG: hsa:2444

STRING: 9606.ENSP00000357615

UniGene: Hs.89426