FTSJ1 Antibody

Datasheet

Citations (1)

Code	CSB-PA009055LA01HU
Size	US$166
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Image	Western blot All lanes: FTSJ1 antibody at 2µg/ml Lane 1: HepG2 whole cell lysate Lane 2: Mouse brain tissue Lane 3: EC109 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 37, 36 kDa Observed band size: 37 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA009055LA01HU at dilution of 1:50
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FTSJ1 Polyclonal antibody

Uniprot No.

Q9UET6

Target Names

FTSJ1

Alternative Names

CDLIV antibody; FTSJ 1 antibody; FtsJ homolog 1 (E. coli) antibody; FtsJ homolog 1 antibody; FtsJ RNA methyltransferase homolog 1 antibody; FTSJ1 antibody; JM23 antibody; Mental retardation X linked 44 antibody; Mental retardation X linked 9 antibody; MRX44 antibody; MRX9 antibody; Protein ftsJ homolog 1 antibody; Putative ribosomal RNA methyltransferase 1 antibody; RRMJ1 antibody; RRMJ1_HUMAN antibody; rRNA (uridine 2' O ) methyltransferase antibody; rRNA (uridine-2''-O-)-methyltransferase antibody; SPB1 antibody; TRM7 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Putative tRNA (cytidine(32)/guanosine(34)-2\\\'-O)-methyltransferase protein (1-329AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FTSJ1 Antibody (Product code: CSB-PA009055LA01HU) is Non-conjugated. For FTSJ1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA009055LB01HU	FTSJ1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009055LC01HU	FTSJ1 Antibody, FITC conjugated
Biotin	CSB-PA009055LD01HU	FTSJ1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

Investigating the Inhibition of FTSJ1 a Tryptophan tRNA-Specific 2′-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR PS Carollo,biochemistry and molecular biology,2023

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : Immunofluorescence microscopy

Sample type: cell

Review: upon FTSJ1 plasmid transfection,CFTR fluorescence intensities decreased in all NV848, NV914, and NV930 treated cells compared to IB3.1 cells treated only with NV molecules in absence of FTSJ1 expression.

By Anonymous

Target Background

Function

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

Gene References into Functions

we have provided strong evidence that human FTSJ1 is required for Cm32 and Gm34 modification of tRNAPhe. PMID: 26310293
May play a role in the regulation of translation. Mutations cause X-linked mental retardation. PMID: 15162322
A splice site mutation is associated with non-syndromic mental retardation in a large Belgian family PMID: 15342698
A 50kb deletion at Xp11.23 including the two genes, SLC38A5 and FTSJ1 was found in 3 brothers with moderate to severe mental retardation. PMID: 17333282
identified a novel FTSJ1 mutation in an X-linked mental retardation family through mutation screening of a cohort of 73 unrelated Japanese male probands with MR PMID: 18081026
Results suggest a positive association between genetic variants and nonsyndromic X-linked mental retardation in young male subjects in the Chinese Han population. PMID: 18401546
These findings suggest that genetic variations in FtsJ homolog 1 (E. coli) possibly influence human cognitive ability. PMID: 19012053
Spb1p is a homologous yeast nucleolar protein PMID: 10648622

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Involvement in disease

Mental retardation, X-linked 44 (MRX44)

Subcellular Location

Cytoplasm.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family, TRM7 subfamily

Tissue Specificity

Found in fetal brain, lung, liver and kidney. In the adult brain, expressed in amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus.

Database Links

HGNC: 13254

OMIM: 300499

KEGG: hsa:24140

STRING: 9606.ENSP00000326948

UniGene: Hs.23170

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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