GABPB1 Antibody

1. Data revealed high expression of GABPB1 in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. Its knockdown significantly decreased the colony formation ability via induction of p21Waf/Cip1 expression. Furthermore, the patients at high risk of a poor survival outcome exhibited the highest expression level of GABPB1. These findings imply that GABPB1 serves an important role in the progression of ccRCC. PMID: 29845229
2. Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells. PMID: 27100840
3. role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. PMID: 28108517
4. GABP beta is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. PMID: 23684612
5. The NRF-2beta nuclear localization signal (NLS) is an unusual but is, nevertheless, a bona fide monopartite-type NLS. PMID: 23856623
6. NRF-1 and GABP expression is coordinated by NRF-1's activation of the GABPbeta promoter PMID: 21609478
7. Data show that BRAF knockdown led to suppression of the expression of the GABPbeta, which involved in regulating HPR1 promoter activity. PMID: 21076620
8. Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. PMID: 12016589
9. Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia [GA-binding protein gamma]. PMID: 16412436
10. serum-responsive GABP binding to Ets-binding sites activates the KIS promoter, leading to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.[NRF-2beta] PMID: 18343819
12. The cyrstal structure of a ternary complex containing the mouse GA binding protein transcription factor, beta subunit 2, was resolved at 2.15 angstrom resolution. PMID: 9461436

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HGNC: 4074

OMIM: 600610

KEGG: hsa:2553

STRING: 9606.ENSP00000220429

UniGene: Hs.654350