GAK Antibody, Biotin conjugated

Code CSB-PA009190LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GAK Polyclonal antibody
Uniprot No.
Target Names
GAK
Alternative Names
Auxilin 2 antibody; Cyclin G associated kinase antibody; Cyclin-G-associated kinase antibody; DNAJ26 antibody; DNAJC26 antibody; EC 2.7.11.1 antibody; FLJ16629 antibody; FLJ40395 antibody; GAK antibody; GAK protein antibody; GAK_HUMAN antibody; MGC99654 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cyclin-G-associated kinase protein (939-1086AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Gene References into Functions
  1. These findings indicate that the abnormal mitoses seen after silencing OIP5-AS1 were caused by an untimely rise in GAK levels and suggest that OIP5-AS1 suppresses cell proliferation at least in part by reducing GAK levels. PMID: 28472763
  2. that the multiple single nucleotide polymorphisms of GAK synergistically participate in the pathogenesis of sporadic Parkinson's disease through multiple pathways. PMID: 26676575
  3. We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7-GAK inhibition increases multipolar mitoses PMID: 28829765
  4. GAK gene expression is increased in Parkinson disease PMID: 27508417
  5. These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system. PMID: 28135906
  6. We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005). PMID: 26318431
  7. This meta-analysis suggests that GAK rs1564282 C/T polymorphism is associated with increased susceptibility to Parkinson's disease--{REVIEW} PMID: 25975492
  8. Data indicated that GBA and TMEM175/GAK significantly alter age at onset in PD. PMID: 25914293
  9. AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively. PMID: 25653444
  10. The effects of rs11248051 and rs1564282 variants of GAK, and the rs3129882 variant of HLA-DRA, were investigated in Parkinson's disease patients. PMID: 24039160
  11. GAK apo structure reveals a dimeric inactive state of the catalytic domain mediated by an unusual activation segment interaction. PMID: 24438162
  12. Cyclin-G-associated kinase is a binding partners of LRRK2, a candidate genes for risk for sporadic Parkinson disease, and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
  13. Dominant negative mutants of IRAK4 and GAK show strong apoptotic effects in A498 cells under anoxia. PMID: 23591012
  14. neither the CT, TT genotypes nor the minor allele T of single nucleotide polymorphism rs1564282 were associated with Parkinson's disease among the subjects from Taiwan and Singapore. PMID: 23826309
  15. rs11248060 significantly increasThis study found that the minor alleles of GAK rpopulationss1564282 and DGKQ e the risk of PD in Han Chinese . PMID: 23618683
  16. GAK as a regulator of dephosphorylation events under the control of the PP2A B'gamma subunit. PMID: 22262175
  17. study demonstrated that the rs1564282 variant in GAK (PARK17) increases the risk of Parkinson's disease in Han Chinese patients from mainland China PMID: 22198721
  18. cyclin G associated kinase is associated with Parkinson disease risk and suggest that cyclin G associated kinase and alpha-synuclein interact in a pathway involved in disease pathogenesis PMID: 21258085
  19. GAK is a new candidate for investigation in future studies. PMID: 21058943
  20. Osteosarcoma cell proliferation and survival are dependent on GAK. PMID: 20881269
  21. results identify a role for GAK and clathrin in microtubule outgrowth from kinetochores/chromosomes and suggest that GAK acts through clathrin to control microtubule outgrowth around chromosomes PMID: 20237935
  22. The GAK localizes in both cytoplasm and nucleus by immunostaining, ectopic expression of GFP-GAK and pull-down assays using dissected GAK fragments. PMID: 19371378
  23. down-regulation of GAK results in outgrowth of cells in soft agar, raising the possibility that loss of GAK function may promote tumorigenesis. PMID: 15240878
  24. GAK enhanced the androgen receptor transcriptional response even at low concentrations of androgens PMID: 16161052
  25. Results describe the recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis. PMID: 16895969
  26. Interactions between the PsiG[PDE][PsiLM]-motif sequences in GAK and the AP1-gamma-ear domain are critical for the recruitment of GAK to the trans-Golgi network and the function of GAK in lysosomal enzyme sorting. PMID: 17538018
  27. GAK and CHC cooperated in the same pathway and interacted in mitosis to regulate the formation of a functional spindle. PMID: 19654208

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Subcellular Location
Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity
Ubiquitous. Highest in testis.
Database Links

HGNC: 4113

OMIM: 602052

KEGG: hsa:2580

STRING: 9606.ENSP00000314499

UniGene: Hs.369607

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