GALK1 Antibody

Code CSB-PA009198LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate
    All lanes: GALK1 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 43, 46 kDa
    Observed band size: 43 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA009198LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GALK1 Polyclonal antibody
Uniprot No.
Target Names
GALK1
Alternative Names
EC 2.7.1.6 antibody; epididymis secretory protein Li 19 antibody; Galactokinase 1 antibody; Galactokinase antibody; Galactose kinase antibody; GALK 1 antibody; GALK antibody; GALK1 antibody; GALK1_HUMAN antibody; GK1 antibody; GLK antibody; GLK1 antibody; HEL-S-19 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Galactokinase protein (23-164AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GALK1 Antibody (Product code: CSB-PA009198LA01HU) is Non-conjugated. For GALK1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009198LB01HU GALK1 Antibody, HRP conjugated ELISA
FITC CSB-PA009198LC01HU GALK1 Antibody, FITC conjugated
Biotin CSB-PA009198LD01HU GALK1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Major enzyme for galactose metabolism.
Gene References into Functions
  1. Mutation in the GALK gene is associated with mental disorders in galactosemia. PMID: 28672748
  2. The GALK1 gene was included in this interval and direct sequencing. PMID: 24211322
  3. Data indicate taht the interactions between galactokinase (GALK) and its potential inhibitors by molecular dynamics simulations. PMID: 23517731
  4. The study highlighted the importance of GALK gene analysis in diagnosis of galactosemia in Indian population. PMID: 22632133
  5. A possible mechanism for the unfolding caused by the Pro(28)Thr point mutation of human galactokinase. PMID: 21264483
  6. Pathogenic mutations in GALK1 that are responsible for autosomal recessive congenital cataracts in consanguineous Pakistani families, are reported. PMID: 20405025
  7. 2 new GALK1 mutations near the ATP-binding site were found in a homozygotic Turkish immigrant: S142I and G148C. PMID: 11978883
  8. a functional analysis of disease-causing mutations in this enzyme PMID: 12694189
  9. In this northern Italian population age-related cataract does not appear to be associated with GALK1 alleles. PMID: 12942049
  10. structure and function of galactokinase, and role in type II galactosemia [review] PMID: 15526155
  11. active site geometry of this enzyme upon which to more fully understand the consequences of the those mutations known to give rise to Type II galactosemia. PMID: 15590630
  12. Mutations in GALK1 resulted in reduction of GALK activity and caused GALK deficiency. PMID: 17517531
  13. These results suggest that the elevated GALK1 activity resulted from enhanced gene expression, due to nucleotide variation within GALK1 promoter PMID: 19309526
  14. Structure of the human enzyme complexed with MgAMP.PNP and galactose PMID: 15590630
  15. The disease-causing point mutations in the human enzyme are mapped onto the structure of the protein from Pyrococcus furiosus and speculations made about the structural consequences. PMID: 15003454
  16. 2-deoxy-D-galactose is a substrate for this enzyme. D-glucose, D-fucose, L-arabinose and N-acetyl-D-galactosamine are not. Mutations H44A, H44I, E43G/H44I are insoluble, D46A is inactive, E43G has reduced activity and E43A has wild-type activity. PMID: 14596685
  17. Has ordered ternary complex mechanism with ATP being the first substrate to bind. PMID: 12694189

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Involvement in disease
Galactosemia II (GALCT2)
Protein Families
GHMP kinase family, GalK subfamily
Database Links

HGNC: 4118

OMIM: 230200

KEGG: hsa:2584

STRING: 9606.ENSP00000225614

UniGene: Hs.407966

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