GALNT11 Antibody, HRP conjugated

Code CSB-PA847687LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GALNT11 Polyclonal antibody
Uniprot No.
Target Names
GALNT11
Alternative Names
A430075I06Rik antibody; AI648252 antibody; E430002F06Rik antibody; FLJ21634 antibody; GalNAc Transferase 11 antibody; GalNAc-T11 antibody; GalNAcT11 antibody; GALNT11 antibody; GLT11_HUMAN antibody; MGC71630 antibody; Polypeptide GalNAc transferase 11 antibody; Polypeptide N-acetylgalactosaminyltransferase 11 antibody; pp-GaNTase 11 antibody; Protein-UDP acetylgalactosaminyltransferase 11 antibody; tcag7.1057 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 antibody; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 11 protein (420-606AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
Gene References into Functions
  1. possible role in the deterioration of kidney function [meta-analysis] PMID: 25493955
  2. evidence suggests that CLL patient samples harbor aberrant O-glycosylation highlighted by Tn antigen expression and that the over-expression of GALNT11 constitutes a new molecular marker for CLL PMID: 24076351
  3. GALNT11, the human ortholog to Drosophila melanogaster pgant35A, was shown not to support rescue of the l(2)35Aa lethality during Drosophila embryogenesis. PMID: 20422447
  4. Single nucleiotide polymorphism in the GALNT11 genes were investigated to assess allele frequencies in different populations. This SNP would be useful marker for forensic individualization, in particular, as ancestry-informative markers. PMID: 20547088
Involvement in disease
Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.
Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 2 family, GalNAc-T subfamily
Tissue Specificity
Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli.
Database Links

HGNC: 19875

OMIM: 615130

KEGG: hsa:63917

STRING: 9606.ENSP00000315835

UniGene: Hs.647109

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