GAST Antibody

1. We concluded that low serum gastrin is related to increased risk of ER(+) BC development. The results also established that CCKBR/ERK/P65 signaling function is generally tumor suppressive in ER(+) BC, indicating therapies should focus on restoring, not inhibiting, CCKBR/ERK/P65 pathway activity. PMID: 30115027
2. Study reveals that Galphas binds to RGS1 and plays a necessary role during RGS1mediated promotion of melanoma proliferation and migration. PMID: 29620236
3. Gastrin and BCL2 apoptosis regulator (Bcl2) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features. PMID: 29268861
4. Everolimus down-regulates the systemic levels of gastrin and glucagon in patients with pancreatic neuroendocrine tumors. PMID: 28609362
5. we suggest that gastrin contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1 PMID: 28498440
6. Results demonstrate that gastrin increases the expression of the autophagy markers MAP1LC3B-II and SQSTM1 in gastric adenocarcinoma cells. Gastrin induces autophagy via activation of the STK11-PRKAA2-ULK1 and that this signaling pathway is involved in increased migration and cell survival. PMID: 28109268
7. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis. PMID: 28408643
8. Gastrin is expressed in both insulin(+) and somatostatin(+) cells in adults with type 2 diabetes. PMID: 27864307
9. Gastrin induced ABCG2 expression by activating NF-kappaB and thereby modulated the side population proportion, tumor cell metastatic potential and invasion activity in pancreatic cancer. PMID: 27264047
10. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells. PMID: 27179776
11. Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin, glucagon, and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients. PMID: 26684862
12. Gastrin role in gastric epithelial homeostasis and gastric carcinogenesis PMID: 25752269
13. Results suggest a role for Toll-like receptor 4 in gastric acid regulation and that the Toll-like receptor 4 (TLR4) +896 and +1196 wild type homozygozity increases peptic ulcer risk via gastrin secretion. PMID: 26161647
14. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17] PMID: 22066020
15. treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene)). PMID: 25601282
16. Gastrin stimulates MMP-1 expression in gastric epithelial cells and stimulates cell migration. PMID: 25977510
17. Progastrin is a new pro-angiogenic factor in colorectal cancer and an attractive therapeutic target. PMID: 25109333
18. Small (PMID: 25993755
19. Gastrin values were higher in erosive esophagitis patients taking proton pump inhibitors compared to controls. There was no correlation between gastrin levels and treatment duration. Female patients had significantly higher gastrin values than males. PMID: 24210828
20. In autoimmune gastritis, the authors were able to find evidence for a new gastrin-mediated mechanism for ghrelin suppression as a gastro-protective marker. PMID: 24388886
21. NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells. PMID: 24086717
22. A novel signal pathway involved in gastrin-stimulated AE2 expression mediated by EGR1 in gastric cancer cells. PMID: 23121767
23. Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin. PMID: 22532184
24. hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms PMID: 22593272
25. The low serum levels of pepsinogen and G17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer. PMID: 21222340
26. progastrin predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps PMID: 22366915
27. analysis of serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy PMID: 22112435
28. gastrin-17 has a role in antral atrophy PMID: 22037174
29. Helicobacter Pylori CagA protein activates the gastrin promoter to up-regulate gastrin mRNA expression through the JAK2-signaling pathway in gastric cancer cells. PMID: 21509655
30. Data show that alphav integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion. PMID: 22110279
31. Data suggest that elevated plasma gastrin and suppression of fasting ghrelin in patients with gastric cancer indicate a close relationship between these two hormones in gastric carcinogenesis. PMID: 21274374
32. CagA may activate the gastrin promoter and up-regulate the expression of gastrin. PMID: 21029692
33. Pancreatic cancer cells produce CCK and gastrin; however, the autocrine production of gastrin is more important for stimulating tumor growth. PMID: 21186400
34. Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. PMID: 21111741
35. No correlation was found between gastrin-17 levels and the degree of corpus atrophy in gastroesophageal reflux patients. PMID: 21175799
36. iron binding to progastrin may regulate processing and secretion in vivo, and regulation may be particularly important in diseases with altered iron homeostasis. PMID: 21195058
37. a positive-feedback loop whereby gastrin, acting via the CCK2 receptor, increases its own expression PMID: 20932834
38. Data show an increasing tendency in the expressions of GAS and SS in children with chronic gastritis and duodenal ulcer. PMID: 17229384
39. Progastrin/glycine extended gastrin stimulation of colorectal mucosa proliferation is dependent on the presence of ferric ions. PMID: 20395538
40. In patients with autoimmune Addison's disease hyperchromograninemia and hypergastrinemia occur with a prevalence of 27.5 and 22.5%, respectively. PMID: 19794299
41. Preprandial oral dose of sitagliptin does not affect circulating gastrin, but it increased gastrin levels after meal loading. PMID: 20145424
42. The mRNA and protein expressions of GAS in well and moderately differentiated colorectal cancers were significantly lower than those in poorly differentiated cancers. PMID: 19031134
43. there was a significant decrease in gastrin plasma concentrations in patients with diabetic autonomic neuropathy PMID: 11710799
44. present in human colorectal adenocarcinomas and liver metatases PMID: 12174892
45. Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor. PMID: 12612900
46. Serum progastrin and gastrin levels are significantly higher in GC patients than in matched controls, confirming that both gastrins may be implicated in gastric carcinogenesis. PMID: 14627349
47. the dibasic processing sites constitute the most important sorting domain of progastrin PMID: 14660571
48. Differentially expressed in gastric cancer and intestinal metaplasia. PMID: 14719064
49. Human gastric carcinomas and gastric cancer cell line SGC-7901 cells coexpress CCK-B receptor and gastrin mRNA. PMID: 15040018
50. gastric hormone gastrin stimulates gastric acid secretion and epithelial cell proliferation--REVIEW PMID: 15533775

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HGNC: 4164

OMIM: 137250

KEGG: hsa:2520

STRING: 9606.ENSP00000331358

UniGene: Hs.2681