GCM1 Antibody

1. our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. PMID: 28515447
2. results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 acetylation and sumoylation. PMID: 28383551
3. Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities. PMID: 27996093
4. Twist1 may promote trophoblast syncytialization by regulating the expression of GCM1. PMID: 26992674
5. GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion. PMID: 26899996
6. GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization. PMID: 26769961
7. reveals a positive feedback loop between glial cells missing 1 and Human chorionic gonadotropin regulating placental hCGbeta expression and cell differentiation PMID: 26503785
8. Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development. PMID: 23580611
9. study reveals a novel function for RACK1 to regulate GCM1 activity and placental cell migration and invasion PMID: 23651062
10. GCM1-directed villous trophoblast differentiation is repressed by DREAM PMID: 23300953
11. c-Myc-regulated members of the miR-17~92 and miR-106a~363 clusters inhibit trophoblast differentiation by repressing GCM1 and CYP19A1. PMID: 23438603
12. Phorbol 12-myristate 13-acetate-induced protein kinase C and mitogen-activated protein kinase kinase/extracellular signal regulated kinase dependent pathway enhances the degradation as well as the transcriptional activity of GCMa. PMID: 22975632
13. study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia PMID: 22778138
14. Data show that beta-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells. PMID: 22109522
15. results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans. PMID: 22275534
16. these data demonstrate for the first time that GCMa is phosphorylated by the PKC- and MEK/extracellular signal-regulated kinase (ERK)-dependent mechanism, and that this phosphorylation is involved in its degradation process. PMID: 22206674
17. CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression. PMID: 19692500
18. Our study has identi fi ed a novel cAMP/Epac1/CaMKI/GCM1 signaling cascade that stimulates trophoblast fusion through promoting GCM1 phosphorylation and desumoylation. PMID: 21791615
19. TIMP4 is a downstream target of GCM1. PMID: 21406447
20. Our results suggest that GCM1 is a critical factor in controlling placental cell fusion through transcriptional regulation of syncytin 2 and MFSD2A gene expression in placenta. PMID: 20484742
21. The researchers found evidence that GCM1 is a potential susceptibility or marker gene for IGA nephropathy. PMID: 19890582
22. GCMa regulates the syncytin-mediated trophoblastic fusion in human cells PMID: 12397062
23. Results suggest that GCM1 is a distinct transcription factor involved in placental disease and altered expression of the GCM1 gene may contribute to the etiology of pre-eclampsia. PMID: 15081636
24. GCM1 transcription factor expression is regulated both at the transcriptional and translational level and these studies show that the general features of GCM1 mRNA and protein expression in the human placenta are conserved with the mouse PMID: 15135239
25. the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system PMID: 15640526
26. GCMa-driven syncytin expression is the key mechanism for syncytiotrophoblast formation PMID: 16004993
27. GCMa acetylation is mediated by CBP, which stimulates GCMa transcriptional activity through cyclic AMP/protein kinase A signaling PMID: 16166624
28. Results suggests that histone deacetylase 3 can functionally attenuate the CBP-upregulated GCMa activity in the activated signaling pathway leading to placental cell fusion. PMID: 16528103
29. Plasma placenta-specific 1 and GCM1 mRNAs appear promising as noninvasively measurable molecular markers for pre-eclampsia PMID: 16594548
30. GCMa is a new sumoylation substrate and its activity is down-regulated by sumoylation. PMID: 17646165
31. Ther is a functional role for GCM1 contributing to constitutively high trophoblast PGF expression and is the first direct evidence of an oxygen-responsive, trophoblast-specific transcription factor contributing to the regulation of PGF expression. PMID: 18160678
32. A central role for GCM1 protein in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in human placental development. PMID: 19219068
33. Severe hypoxia is associated with reduced GCMa and syncytin-1 transcripts and altered fusion of primary trophoblasts. PMID: 19321927

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HGNC: 4197

OMIM: 603715

KEGG: hsa:8521

STRING: 9606.ENSP00000259803

UniGene: Hs.23589