GFRA3 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA009381LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GFRA3 Polyclonal antibody

Uniprot No.

O60609

Target Names

GFRA3

Alternative Names

GDNF family receptor alpha 3 antibody; GDNF family receptor alpha-3 antibody; GDNF receptor alpha-3 antibody; GDNFR-alpha-3 antibody; GDNFR3 antibody; GFR-alpha-3 antibody; GFRA3 antibody; GFRA3_HUMAN antibody; Glial cell line derived neurotrophic factor receptor alpha 3 antibody; GPI linked receptor antibody; OTTHUMP00000159486 antibody; OTTHUMP00000224020 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GDNF family receptor alpha-3 protein (32-236AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Gene References into Functions

increased GFRalpha3 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma PMID: 28651425
Mir-34a directly regulates GFRA3 via its coding region.GFRA3 is crucial for breast cancer growth. PMID: 28356515
The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. PMID: 26984265
The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas. PMID: 22031517
Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma. PMID: 19304517
1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3 was reported. PMID: 16765900
In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRalpha3- and RET-like staining, suggesting co-localization. PMID: 16773224

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

GDNFR family

Tissue Specificity

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non

Database Links

HGNC: 4245

OMIM: 605710

KEGG: hsa:2676

STRING: 9606.ENSP00000274721

UniGene: Hs.58042

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Service

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Protein Service

Gene Synthesis Service

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Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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