GID8 Antibody, Biotin conjugated

Code CSB-PA882124LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GID8 Polyclonal antibody
Uniprot No.
Target Names
GID8
Alternative Names
GID8 antibody; C20orf11 antibody; TWA1Glucose-induced degradation protein 8 homolog antibody; Two hybrid-associated protein 1 with RanBPM antibody; Twa1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glucose-induced degradation protein 8 homolog protein (1-228AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Gene References into Functions
  1. The results identify Twa1 as a previously undescribed regulator of the Wnt pathway for promoting colorectal tumorigenesis by facilitating beta-catenin nuclear retention. PMID: 28829046
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
GID8 family
Tissue Specificity
Up-regulated in colorectal cancer tissues (at protein level).
Database Links

HGNC: 15857

OMIM: 611625

KEGG: hsa:54994

STRING: 9606.ENSP00000266069

UniGene: Hs.353013

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