GLIS2 Antibody, Biotin conjugated

Code CSB-PA861185LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GLIS2 Polyclonal antibody
Uniprot No.
Target Names
GLIS2
Alternative Names
FLJ38247 antibody; GLI similar 2 antibody; GLI-similar 2 antibody; GLIS 2 antibody; GLIS family zinc finger 2 antibody; glis2 antibody; GLIS2_HUMAN antibody; Kruppel like zinc finger protein GLIS2 antibody; Neuronal Krueppel-like protein antibody; Zinc finger protein GLIS2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
Gene References into Functions
  1. CBFA2T3-GLIS2 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome. PMID: 28063190
  2. specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia. PMID: 28292442
  3. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary. PMID: 27094503
  4. Nephronophthisis 7-related mutation C175R affects both localization and function of GLIS2 protein. PMID: 26374130
  5. Glis2/NPHP7 is extensively modified by post-translational modifications PMID: 26083374
  6. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML. PMID: 24127550
  7. BBS11 promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 Modulates the Transcriptional Activities of Glis2 PMID: 24500717
  8. Recessive mutation in GLIS2 gene is associated with Caroli disease. PMID: 23559409
  9. Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein. PMID: 23153540
  10. Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity PMID: 21127075
  11. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions PMID: 11741991
  12. Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription. PMID: 17289029
  13. identification of Gli-similar 2 (Glis2) as a novel binding protein for p120 catenin PMID: 17344476
  14. Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis. PMID: 17618285

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Involvement in disease
Nephronophthisis 7 (NPHP7)
Subcellular Location
Nucleus speckle. Cytoplasm.
Protein Families
GLI C2H2-type zinc-finger protein family
Tissue Specificity
Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
Database Links

HGNC: 29450

OMIM: 608539

KEGG: hsa:84662

STRING: 9606.ENSP00000262366

UniGene: Hs.592087

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