GLIS2 Antibody, FITC conjugated

Datasheet
Code CSB-PA861185LC01HU
Size US$299
Uniprot No. Q9BZE0
Immunogen Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein), GLIS2, NKL
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names GLIS2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Involvement in disease Nephronophthisis 7 (NPHP7)
Subcellular Location Nucleus speckle, Cytoplasm
Protein Families GLI C2H2-type zinc-finger protein family
Tissue Specificity Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
Database Links

HGNC: 29450

OMIM: 608539

KEGG: hsa:84662

STRING: 9606.ENSP00000262366

UniGene: Hs.592087

Related Products

GLIS2 Antibodies

GLIS2 Antibodies for Human

GLIS2 Antibodies for Homo sapiens (Human)

GLIS2 Proteins

GLIS2 Proteins for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.