GNA15 Antibody

1. GNA15 was not expressed in normal neuroendocrine cells but was overexpressed in gastroenteropancreatic neuroendocrine neoplasia cell lines. PMID: 25701539
2. Data indicate the importance of Galpha16 as a downstream effector of the non-canonical Wnt signaling pathway and as a potential therapeutic target for the treatment of non small cell lung cancer. PMID: 24204697
3. G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients. PMID: 23200847
4. The paper describes G alpha 15 resistance to arrestin-desensitization making it differ from other heterotrimeric G proteins (Gq, Gs, Gi, G12/13 class) PMID: 19275934
5. This paper shows how G alpha 15 and other Gq class members phosphorylate PKD in differing patterns PMID: 22227248
6. This review summarizes the specific features that distinguish Galpha15/GNA15 (G15 alpha subunit) from all other alpha subunits of the Gq class. G15 is a heterotrimeric G protein complex that is named after its alpha subunit. PMID: 20150327
7. beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras PMID: 21486497
8. Megakaryocytopoiesis was accompanied by down-regulation of the 43 kDa and 46 kDa variants of G16alpha, constant expression of Gsalpha, and up-regulation of Gqalpha and Gialpha1/2. PMID: 11686331
9. role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16. PMID: 12095632
10. G protein-coupled receptors activate STAT3 via G alpha(16), a G alpha subunit which is primarily expressed in hematopoietic cells. PMID: 12670499
11. Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism PMID: 14551213
12. Results suggest that the G(q) class proteins are degraded through the proteasome pathway and that cellular localization and/or other protein interactions determine their stability. PMID: 16218966
13. Co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP. PMID: 18755267
14. The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. PMID: 19687291

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HGNC: 4383

OMIM: 139314

KEGG: hsa:2769

STRING: 9606.ENSP00000262958

UniGene: Hs.73797