GNB4 Antibody

Datasheet

Code	CSB-PA862056LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat liver tissue, Mouse liver tissue, Mouse kidney tissue All lanes: GNB4 antibody at 2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38 kDa Observed band size: 38 kDa Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA862056LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA862056LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA862056LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GNB4 Polyclonal antibody

Uniprot No.

Q9HAV0

Target Names

GNB4

Alternative Names

G protein beta 4 subunit antibody; GBB4_HUMAN antibody; GNB 4 antibody; Gnb4 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 4 antibody; Guanine nucleotide binding protein beta 4 subunit antibody; Guanine nucleotide binding protein beta polypeptide 4 antibody; Guanine nucleotide binding protein beta subunit 4 antibody; Guanine nucleotide binding protein subunit beta 4 antibody; Guanine nucleotide-binding protein subunit beta-4 antibody; Transducin beta chain 4 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GNB4 Antibody (Product code: CSB-PA862056LA01HU) is Non-conjugated. For GNB4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA862056LB01HU	GNB4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA862056LC01HU	GNB4 Antibody, FITC conjugated
Biotin	CSB-PA862056LD01HU	GNB4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene References into Functions

GNB4 is important for growth of breast cancer cells and a potential target for treatment PMID: 30103729
A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population. PMID: 28642160
Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling. PMID: 25916507
Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation. PMID: 23434117
Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells. PMID: 12454992
Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5 PMID: 12782285
Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer. PMID: 18815590
Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma. PMID: 19414374

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Involvement in disease

Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)

Protein Families

WD repeat G protein beta family

Tissue Specificity

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.

Database Links

HGNC: 20731

OMIM: 610863

KEGG: hsa:59345

STRING: 9606.ENSP00000232564

UniGene: Hs.173030

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Chemokine signaling pathway PI3K-Akt signaling pathway Ras signaling pathway Apelin signaling pathway Glutamatergic synapse

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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