GPR137 Antibody

Code CSB-PA009752GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GPR137
Alternative Names
GPR137; C11orf4; GPR137A; TM7SF1L1; Integral membrane protein GPR137; Transmembrane 7 superfamily member 1-like 1 protein
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GPR137
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy.; May activate Wnt/beta-catenin signaling to modulate epithelial cell function.
Gene References into Functions
  1. High GRP137 expression is associated with metastasis in ovarian cancer. PMID: 29739299
  2. findings imply that GPR137 plays an important role in the occurrence and progression of PCa and may prove to be a potential therapeutic target for the treatment of advanced PCa PMID: 26669804
  3. GPR137 as an essential player in urinary bladder cancer cell growth PMID: 25496438
  4. GPR137 knockdown inhibited growth of Daoy medulloblastoma cells via disturbing cell cycle progression and inducing apoptosis PMID: 25524330
  5. GPR137 as a potential oncogene in pancreatic cancer cells PMID: 25471990
  6. Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which contributed to cell growth inhibition. PMID: 25490967
  7. Our results indicated that GPR137 is involved in the progression of human glioma PMID: 24870220
  8. Expression levels of GRP137 were analyzed in different colon cancer cell lines. Silencing of GPR137 reduced the proliferation rate and colony numbers. PMID: 25301753

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Subcellular Location
Lysosome membrane; Multi-pass membrane protein.
Protein Families
GPR137 family
Database Links

HGNC: 24300

KEGG: hsa:56834

STRING: 9606.ENSP00000411827

UniGene: Hs.523763

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