GPRASP1 Antibody

Code CSB-PA009848GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GPRASP1
Alternative Names
G-protein coupled receptor-associated sorting protein 1 antibody; GASP antibody; GASP-1 antibody; GASP1 antibody; GASP1_HUMAN antibody; Gprasp1 antibody; KIAA0443 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human GPRASP1-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
Form
Liquid
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
Gene References into Functions
  1. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 PMID: 25706089
  2. Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1. PMID: 23082996
  3. GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas. PMID: 22483848
  4. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. PMID: 21900845
  5. These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer. PMID: 21791203
  6. following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1) PMID: 21030592
  7. This review describes the discovery of GASPs, their major features, interacting partners, functions and possible involvement in pathological situations including neurodegenerative diseases and cancer. PMID: 20394773
  8. identified a protein that binds preferentially to the cytoplasmic tail of the delta opioid receptor as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP) [GASP] PMID: 12142540
  9. Modulation of the D2-GASP interaction is important for the functional down-regulation of D2 dopamine receptors. PMID: 16049099

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Subcellular Location
Cytoplasm.
Protein Families
GPRASP family
Tissue Specificity
Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
Database Links

HGNC: 24834

OMIM: 300417

KEGG: hsa:9737

STRING: 9606.ENSP00000355146

UniGene: Hs.729265

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