GRIK1 Antibody

1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. PMID: 27447243
2. The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking. PMID: 25496338
3. Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
4. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
5. In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. PMID: 25941919
6. This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period. PMID: 24786948
7. These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight. PMID: 24978347
8. Topiramate treatment for alcohol dependence was significantly more effective in rs2832407 C-allele homozygotes. PMID: 24525690
9. Reduced Homer binding to mGluR5 supports an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. PMID: 23685007
10. Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India. PMID: 22931243
11. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. PMID: 22807686
12. GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples PMID: 22730074
13. Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2+ influx. PMID: 20848601
14. The amino acid sequence of the GluK1 kainate receptor near or within the carboxyl-terminal endoplasmic reticulum retention signal sequence, which affects receptor trafficking and/or expression, does not affect channel gating properties. PMID: 22191429
15. The GRIK1 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
16. findings show GluR5 was upregulated in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy (TLE)compared to controls; mossy fiber sprouting in the hippocampus of TLE patients was correlated with GluR5 upregulation PMID: 19941835
17. Variation in the 3' portion of the gene encoding the GluR5 kainate receptor subunit contributes to the risk for alcohol dependence. PMID: 19320626
18. GluK1 kainate receptor polymorphisms are associated with Down syndrome. PMID: 19893199
19. GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population PMID: 11702055
20. there are trafficking signals in the C-terminal domain of GluR5-2b; alternative splicing is an important mechanism regulating KAR function PMID: 14527949
21. Two amino acids,competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. PMID: 15974569
22. This kainate receptor subunit appears to be selectively altered in the anterior cingulate cortex in schizophrenia and bipolar disorder. PMID: 17698324

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HGNC: 4579

OMIM: 138245

KEGG: hsa:2897

STRING: 9606.ENSP00000382791

UniGene: Hs.664641