GRIK2 Antibody, FITC conjugated

Code CSB-PA618751LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GRIK2 Polyclonal antibody
Uniprot No.
Target Names
GRIK2
Alternative Names
bA487F5.1 antibody; EAA4 antibody; Excitatory amino acid receptor 4 antibody; GLR 6 antibody; GLR6 antibody; GluK2 antibody; GLUK6 antibody; GLUR 6 antibody; GluR-6 antibody; GluR6 antibody; Glutamate receptor 6 antibody; Glutamate receptor antibody; glutamate receptor form A antibody; glutamate receptor form B antibody; glutamate receptor form C antibody; glutamate receptor form D antibody; glutamate receptor form E antibody; Glutamate receptor ionotropic kainate 2 antibody; GRIK 2 antibody; GRIK2 antibody; GRIK2 protein antibody; GRIK2_HUMAN antibody; ionotropic kainate 2 antibody; MRT6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glutamate receptor ionotropic, kainate 2 protein (203-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons.
Gene References into Functions
  1. results suggest that PKC SUMOylation is an important regulator of the 14-3-3 and GluK2a protein complex and may contribute to regulate the decay kinetics of kainate receptor-excitatory postsynaptic currents PMID: 28837400
  2. these findings indicate that GRIK2 has a role in the maintenance of urothelial cancer stem cells and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas PMID: 28418868
  3. TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis. PMID: 27607061
  4. In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility. PMID: 27324535
  5. Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner PMID: 26277340
  6. This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression. PMID: 24662927
  7. This study showed that Gluk2 association with obsessive-compulsive disorder. PMID: 24821223
  8. Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function. PMID: 25316086
  9. High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars. PMID: 25842862
  10. The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke. PMID: 25201974
  11. we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients PMID: 23660601
  12. Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. PMID: 23713029
  13. 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. PMID: 23861400
  14. Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis PMID: 23400781
  15. Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes GRIK2. PMID: 23037145
  16. The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. PMID: 22429480
  17. Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease. PMID: 22771793
  18. Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS. PMID: 21912186
  19. Genotyping and linkage analysis excluded linkage of the GRIK2 gene and TUSC3 gene with mental retardation. PMID: 21557188
  20. This study supports previously reported findings of association between proximal GRIK2 single nucleotide polymorphism and obsessive-compulsive disorder in a comprehensive evaluation of the gene PMID: 20370803
  21. human GluK2 is a slowly activating channel but more sensitive to glutamate, as compared to the rat ortholog; the M867I mutation does not affect the rate the equilibrium constants of the channel opening but does slow down the channel desensitization rate PMID: 20863077
  22. Spliced variants of ionotropic glutamate receptor GluR6 is associated with astrocytoma. PMID: 20230879
  23. phosphorylation of PKC sites on GluR6 regulates surface expression of GluR6 at distinct intracellular trafficking pathways PMID: 19920140
  24. Linkage and association of the glutamate receptor 6 gene with autism PMID: 11920157
  25. Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
  26. describes the time course of the open-channel form of the receptor as a function of glutamate concentration PMID: 14567698
  27. Using three single nucleotide polymorphisms in GRIK2 and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses. PMID: 15094479
  28. In this study, the maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. PMID: 15305151
  29. The modifier effect is actually due to the TAA repeat itself, possibly via a functional consequence on the GRIK2 mRNA. PMID: 16959037
  30. Our data on altered functional properties of GluR6(M836I) provide a functional basis for the postulated linkage of GluR6 to autism. PMID: 17167233
  31. phosphorylation of the C-terminal tail of GluR6 by PKA leads to potentiation of whole cell response PMID: 17379418
  32. These results suggest a potential association between GRIK2 and autism in the Korean population. PMID: 17428563
  33. Mutations of GluR6 are unlikely to be associated with autism in the Indian population. PMID: 17712621
  34. report a complex mutation in the ionotropic glutamate receptor 6 gene (GRIK2, also called "GLUR6") that cosegregates with moderate-to-severe nonsyndromic autosomal recessive mental retardation in a large, consanguineous Iranian family PMID: 17847003
  35. Overall, our data indicate that hGluR6c might have unique properties in non-nervous cells and in the first stages of CNS development. PMID: 18289788
  36. the apo state of GluR6 undergoes a cleft closure of 29-30 degrees upon binding full agonists, one of the largest observed in the glutamate receptor family. PMID: 18658129
  37. Mutations to GLUR6 binding pocket that selectively affect domoate binding are freported. PMID: 18664604
  38. nonconserved residues in GluR6 define the size of the agonist-binding pocket, exerting a steric influence on the bound agonist and the extent of binding-domain closure PMID: 18690046
  39. GluR6 C-terminal domain KRIP6 regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect PMID: 18692513
  40. in silico ligand-docking predicted that most partial agonists select for the closed and not, as expected, the open or intermediate conformations of the GluK2 agonist binding domain. PMID: 19225180
  41. Results indicate that ions can contribute substantial free energy to active state stabilization in GluR6, and provide quantitative measurements of the energetic consequences of allosteric ion binding to a ligand-gated ion channel. PMID: 19617541

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Involvement in disease
Mental retardation, autosomal recessive 6 (MRT6)
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK2 subfamily
Tissue Specificity
Expression is higher in cerebellum than in cerebral cortex.
Database Links

HGNC: 4580

OMIM: 138244

KEGG: hsa:2898

STRING: 9606.ENSP00000397026

UniGene: Hs.98262

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