GRPR Antibody

1. Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters PMID: 28280221
2. GRP-R regulates glucose metabolism in neuroblastoma by modulating HIF-1alpha, PDK4 and PDP2. PMID: 25630799
3. BBS caused a significant increase in Shh gene transcription and protein secretion that was dependent on BBS-induced GPCR/Galphaq-//Rho mediated activation of nuclear factor kappaB (NFkappaB), which can stimulate a NF-kappaB response element in the Shh gene promoter PMID: 24747971
4. GRPR is highly expressed in epidermoid carcinoma of the anal canal, suggesting this receptor might have a role in anal carcinogenesis. PMID: 23958544
5. a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG-RhoA-ROCK pathway. PMID: 24958816
6. GRPR expression was more pronounced in an advanced-stage lung cancer PMID: 24377816
7. integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion PMID: 23889963
8. Elevated buccal GRPR espression was significantly associated with squamous cell carcinoma of the head and neck. PMID: 22431275
9. These findings highlight the role of GRPR signaling in sepsis outcome. PMID: 22735756
10. Protein kinase C is critically responsible for rapid VEGF secretion by gastrin-releasing peptide receptor signaling in neuroblastoma cells PMID: 23155231
11. High GRPR is associated with prostate carcinoma. PMID: 22248281
12. Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. Lung cancer risk was not modified by sex. PMID: 22296774
13. Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors provides molecular basis for dual targeting of tumoral vasculature. PMID: 21605611
14. This study is the first to confirm the presence of gastrin-releasing peptide receptor in human glioma specimens and normal human neurons. PMID: 20211708
15. The results suggest that brain-derived neurotrophic factor/TrkB and cAMP phosphodiesterase-4, but not the gastrin-releasing peptide receptor, regulate the viability of medulloblastoma cells. PMID: 19642024
16. hGRP-R activation stimulated sustained cyclic AMP response element binding protein (CREB) phosphorylation and transactivation in duodenal cancer cells through a protein kinase C and partially p38 mitogen-activated protein kinase-dependent pathway. PMID: 12220644
17. Bombesin-dependent activation (through GRP receptor) of the transcription factor Elk-1 and significant increase of cell proliferation in prostate cancer cell lines PMID: 12409226
18. accumulation of mutations within the GRPR gene allows for the dedifferentiation of tumor cells within any particular colon cancer; poorly-differentiated tumor cells within any individual cancer may arise clonally from better-differentiated precursors PMID: 12720295
19. Increased gastrin-releasing peptide (GRP) receptor expression in small cell lung cancer cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition PMID: 12771999
20. The expression of GRP-R in uterine tissue during specific phases of the cycle suggests a timely precise physiological action of GRP in these targets; in certain uterine neoplasms, the GRP-R overexpression may contribute to tumor development PMID: 15941862
21. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells PMID: 15967120
22. GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors. PMID: 17349623
23. The large amounts of GRP-receptors in ovarian tumor vessels suggest a role in tumoral vasculature and possibly angiogenesis. PMID: 17726264
24. There is a potential role of C6S and L181F mutations on GRPR function, and possibly in the pathogenesis of the autistic disorders. PMID: 18393381
25. CREB is a critical regulator of human GRP-R expression in gastrointestinal cancer and might be activated through different upstream intracellular pathways PMID: 18483184
26. Widespread GRPR expression in human cervical cancer. PMID: 18497507
27. These findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. PMID: 18753628
28. Gastrin-releasing peptide receptor is expressed in the vast majority of lymph node metastases and in 52.9% of bone metastases of prostate cancer. PMID: 19343734
29. High expression of gastrin-releasing peptide receptors is associated with the vascular bed of urinary tract cancers. PMID: 19478282
30. In MDA-MB-231 breast cancer cells, GRP-R and EGF-R synergize to regulate cell migration and IL-8 expression, but not cell proliferation. PMID: 19631337

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HGNC: 4609

OMIM: 305670

KEGG: hsa:2925

STRING: 9606.ENSP00000369643

UniGene: Hs.567282