GSPT1 Antibody

1. PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination. PMID: 27418677
2. Data found that the N-terminal glycine repeat of eRF3a influences eRF3a-PABP interaction and that eRF3a 12-GGC allele has a decreased binding affinity for PABP. PMID: 26818177
3. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor. PMID: 26503584
4. The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis. PMID: 23377885
5. Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. PMID: 25028095
6. The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF. PMID: 24569073
7. ERF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis. PMID: 23054082
8. Our results show that the presence of the longer allele of eRF3a is correlated with threefold increased risk of breast cancer development PMID: 22101789
9. A biological role for the overlapping ERF3 PAM2 motifs in the regulation of deadenylase accessibility to PABPC1 at the 3' end of poly(A). PMID: 23019593
10. crystal structures of the MLLE domain from PABPC1 in complex with the two PAM2 regions of eRF3 PMID: 20418951
11. GSPT1/eRF3 is proteolytically processed into an IAP-binding protein PMID: 12865429
12. Human translation termination factor eRF3/GSPT1 is an interacting partner of RNase L. PMID: 15908960
13. Polyglycine expansions in eukaryotic translation release factor 3 are associated with gastric cancer susceptibility PMID: 15987717
14. eRF3a controls the formation of the termination complex by modulating eRF1 protein stability. PMID: 15987998
15. Further, we describe a novel complex that contains the NMD factors SMG-1 and Upf1, and the translation termination release factors eRF1 and eRF3 (SURF). an association between SURF and the EJC is required for SMG-1-mediated Upf1 phosphorylation and NMD. PMID: 16452507
16. GSTP1 inhibits the binding of MAP kinase kinase kinase 5 (MAP3K5) to the 14-3-3 protein, a MAP3K5 inhibitor, while a novel role of GSPT1 is revealed in the regulation of apoptosis signal-regulating kinase 1 (ASK1)-mediated apoptosis. PMID: 17700517
17. eRF3a is degraded by the proteasome when not associated with eRF1; proteasomal degradation of eRF3a controls translation termination complex formation by adjusting the eRF3a level to that of eRF1. PMID: 18083835
18. eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. PMID: 19424636
19. GSPT1 GGC(12) allele was present in 2.2% of colorectal cancer patients but was absent in Crohn disease patients and in the control group PMID: 19963113

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HGNC: 4621

OMIM: 139259

KEGG: hsa:2935

STRING: 9606.ENSP00000398131

UniGene: Hs.528780