GSX2 Antibody, Biotin conjugated

Code CSB-PA009996LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GSX2 Polyclonal antibody
Uniprot No.
Target Names
GSX2
Alternative Names
GS homeobox 2 antibody; GSX2 antibody; GSX2_HUMAN antibody; Homeobox protein GSH 2 antibody; Homeobox protein GSH-2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human GS homeobox 2 protein (15-118AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development. During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons.
Gene References into Functions
  1. Data show that GS Homeobox 2 (Gsx2) and Early B-cell factor 1 (Ebf1) combined overexpression in human embryonic stem (hES) cells achieves high yields of medium spiny neurons (MSNs). PMID: 28137879
  2. 4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset. PMID: 25816740
  3. Gsx2 negatively regulates neurogenesis from postnatal progenitor cells. PMID: 22242181
  4. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. PMID: 21368052
  5. ectopically expressed in myeloid leukemic cells with t(4;12)(q11-q12;p13), suggesting that expression of GSH2 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV6 PMID: 11861295
  6. Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during neurogenesis in transgenic mice. PMID: 19709628

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Antp homeobox family
Database Links

HGNC: 24959

OMIM: 616253

KEGG: hsa:170825

STRING: 9606.ENSP00000319118

UniGene: Hs.371899

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