HAS3 Antibody

1. Study shows that HAS3 is induced by IL-1beta in vascular smooth muscle cells and that HAS3 is critically involved in early macrophage driven inflammation. PMID: 28987865
2. miR-29a-3p can inhibit gastric cancer cells proliferation and metastasis by regulation HAS3 expression. These findings reveal a new mechanism by which, at least partially, miR-29a-3p may act as a candidate tumor suppressor. PMID: 29693123
3. Hyaluronan synthase 3 (HAS3) and tumor necrosis factor-alpha (TNF-alpha) formed an inter-regulation loop to enhance tumorigenesis in oral cancer. PMID: 28107185
4. The study describes novel regulatory mechanisms governed by UDP-sugars in hyaluronan synthesis, i.e. the intracellular trafficking and extracellular shedding of HAS3. The control mechanisms reveal the significance of these glucose metabolites in hyaluronan synthesis, which is particularly important in the interactions of malignant cells with their microenvironment, and hence the progression of tumors, like melanoma. PMID: 26883802
5. Overexpression of HAS3 decreased ERK1/2 phosphorylation suggesting that inhibition of MAP-kinase signaling was responsible for decreased melanoma cell adhesion, migration and proliferation. PMID: 26222208
6. HAS3 underexpression is associated with advanced tumor stage and adverse pathological features, as well as implies inferior clinical outcomes for both groups of patients with UTUCs and UBUCs, suggesting its critical role in tumor progression PMID: 25934334
7. Hyaluronan accumulation by HAS3 favors pancreatic cancer growth. PMID: 25147816
8. Transcriptional factor binding analysis indicated that HAS3 gene promoter lacks of canonical TATA box, but contains classical GC box as well as other putative binding sites for transcriptional factors PMID: 25843802
9. HAS3 mRNA expression level increases in atopic dermatitis lesions compared with healthy and non-lesional skin PMID: 24658508
10. Rab10 silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed hyaluronan synthesis. PMID: 24509846
11. Hyaluronan (HA) produced by HAS3 is a ubiquitous component of the extracellular matrix and plays an active role in tissue remodeling. In addition, HA is known to reduce reactive oxygen species (ROS) -induced cardiac injury. PMID: 24470002
12. Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin. PMID: 20849445
13. Data show that mRNA of HAS isoform 3 (HAS3) was upregulated in ESCC biopsies. PMID: 21429221
14. Hyaluronan and HAS3 function in the growth and progression of colon carcinoma PMID: 14566823

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HGNC: 4820

OMIM: 602428

KEGG: hsa:3038

STRING: 9606.ENSP00000304440

UniGene: Hs.592069