HCN1 Antibody, Biotin conjugated

Code CSB-PA010216LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HCN1 Polyclonal antibody
Uniprot No.
Target Names
HCN1
Alternative Names
BCNG-1 antibody; BCNG1 antibody; Brain cyclic nucleotide gated channel 1 antibody; Brain cyclic nucleotide-gated channel 1 antibody; HAC 2 antibody; HAC2 antibody; HCN1 antibody; HCN1_HUMAN antibody; Hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody; Potassium channel; voltage-gated; brain; 1 antibody; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 antibody; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 protein (784-887AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Gene References into Functions
  1. Polymorphism of HCN1 is associated with breast cancer. PMID: 28178648
  2. Study presents cryo-electron microscopy structures of the human HCN1 channel in the absence and presence of cAMP at 3.5 A resolution. HCN channels contain a K(+) channel selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na(+) and K(+) permeability. PMID: 28086084
  3. A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway. PMID: 25142030
  4. de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans PMID: 24747641
  5. acute abrogation of HCN1-FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies PMID: 24403084
  6. Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders. PMID: 23033536
  7. Wild-type presynaptic HCN1 channel function is persistently decreased following seizures. PMID: 23077068
  8. HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. PMID: 22094222
  9. Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus. PMID: 21562186
  10. Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. PMID: 21615589
  11. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively. PMID: 21504900
  12. Human HCN1 hyperpolarization activated current (Ih) amplitude is rapidly enhanced after establishment of the whole-cell configuration in HEK293 cells. PMID: 20806410
  13. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20145138
  14. Helical secondary structure of the external S3-S4 linker of this pacemaker channel is examined and affects its activation PMID: 12668666
  15. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID: 12890777
  16. In HCN1, the amino acid substitution A881T was identified in one idiopathic generalized epilepsy patient. PMID: 17931874
  17. The polymorphism rs10941679 near HCN1/MRPS30 was also associated with percent dense area in breast cancer. PMID: 19232126
  18. Observational study of gene-disease association. (HuGE Navigator) PMID: 19232126
  19. Observational study of gene-disease association. (HuGE Navigator) PMID: 18454440
  20. Observational study of gene-disease association. (HuGE Navigator) PMID: 17931874
  21. Observational study of gene-disease association. (HuGE Navigator) PMID: 18081024

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Involvement in disease
Epileptic encephalopathy, early infantile, 24 (EIEE24)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Potassium channel HCN family
Tissue Specificity
Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
Database Links

HGNC: 4845

OMIM: 602780

KEGG: hsa:348980

STRING: 9606.ENSP00000307342

UniGene: Hs.353176

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