HECTD3 Antibody, Biotin conjugated

Code CSB-PA725567LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HECTD3 Polyclonal antibody
Uniprot No.
Target Names
HECTD3
Alternative Names
E3 ubiquitin-protein ligase HECTD3 antibody; HECD3_HUMAN antibody; HECT antibody; HECT domain containing protein 3 antibody; HECT domain-containing protein 3 antibody; HECTD3 antibody; Probable E3 ubiquitin protein ligase HECTD3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase HECTD3 protein (682-785AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.
Gene References into Functions
  1. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway. PMID: 28636940
  2. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. PMID: 23358872
  3. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. PMID: 18194665
Subcellular Location
Cytoplasm, perinuclear region.
Database Links

HGNC: 26117

KEGG: hsa:79654

STRING: 9606.ENSP00000361245

UniGene: Hs.525084

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