HECW2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA889188LD01HU
Size US$299
Uniprot No. Q9P2P5
Immunogen Recombinant Human E3 ubiquitin-protein ligase HECW2 protein (495-641AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2), HECW2, KIAA1301 NEDL2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Cell Biology
Target Names HECW2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73
Involvement in disease Neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL)
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, spindle
Tissue Specificity Predominantly expressed in adult brain, lung and heart.
Database Links

HGNC: 29853

OMIM: 617245

KEGG: hsa:57520

STRING: 9606.ENSP00000260983

UniGene: Hs.633212

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