HHLA2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA891555LD01HU
Size US$299
Uniprot No. Q9UM44
Protocols ELISA Protocol
Immunogen Recombinant Human HERV-H LTR-associating protein 2 protein (172-258AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2), HHLA2
Immunogen Species Homo sapiens (Human)
Research Area Immunology
Target Names HHLA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.
Database Links

HGNC: 4905

OMIM: 604371

KEGG: hsa:11148

STRING: 9606.ENSP00000350402

UniGene: Hs.225968

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