HLA-DOA Antibody

1. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID: 27486778
2. significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID: 25758996
3. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
4. HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID: 24530695
5. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID: 24384427
6. results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID: 23222639
7. analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID: 22733780
8. HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
9. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID: 15265882
10. These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID: 15817706
11. four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID: 16101837
12. minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID: 18639552
13. HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID: 19458622

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HGNC: 4936

OMIM: 142930

KEGG: hsa:3111

STRING: 9606.ENSP00000229829

UniGene: Hs.631991